Spatial plasticity of the auditory cortex in single-sided deafness
Spatial plasticity of the auditory cortex in single-sided deafness
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DOI：
10.1002/lary.25961
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发表时间：
2016-12-01
期刊：
影响因子：
2.6
通讯作者：
Cheung, Steven W.
中科院分区：
文献类型：
--
作者：
Chang, Jolie L.;Pross, Seth E.;Cheung, Steven W.
目的/假设评价单侧耳聋（SSD）患者听觉皮层的空间可塑性。研究设计：横断面研究，比较成人发病的特发性SSD队列与听力正常的队列。方法收集13例SSD成人受试者和13例正常听力对照者的人口学、听力、脑磁成像和磁共振成像数据。通过先进的生物磁源成像分析，提取了同侧和对侧听觉皮层对音调刺激（0.5 kHz和4 kHz）对应的M100反应的峰值激活位置。计算了两个半球在0.5 kHz到4 kHz区域的频率表示的空间范围。结果0.5 kHz和4 kHz刺激峰位的空间间隔距离显示，对侧听觉半球的激活传播距离增加，同侧听觉半球的激活传播距离减小。相比之下，对于同侧和对侧输入，正常听力控制在两个半球的激活传播距离几乎相同。与正常对照组的1.7 mm相比，SSD组的半球间激活扩散距离差异显著增加至6.5 mm （P < 0.05）。结论SSD患者单侧外周输入缺失与双半球听觉皮层的空间重组有关。中枢听觉功能组织的这种变化可能反过来导致依赖于半球间加工的高阶听力缺陷。单耳听力优化可能需要修复SSD的空间和时间中枢性听觉变化。证据水平。喉镜杂志，26 (6):2785-2791,2016
Objectives/HypothesisTo evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD).Study DesignCross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing.MethodsDemographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation corresponding to the M100 response in auditory cortices ipsilateral and contralateral to tonal stimuli (0.5 kHz and 4 kHz) were extracted from advanced biomagnetic source imaging analyses. Spatial extent of frequency representation across the 0.5 kHz to 4 kHz zone was computed for the two hemispheres.ResultsSpatial separation distance between peak locations for 0.5 kHz and 4 kHz stimuli in SSD showed increased activation spread distance in the hemisphere contralateral to the only hearing ear and decreased distance in the ipsilateral hemisphere. In contrast, normal hearing controls had nearly the same activation spread distance in the two hemispheres for ipsilateral and contralateral inputs. The difference between interhemispheric activation spread distance in SSD is significantly increased to 6.5 mm, when compared to 1.7 mm in normal controls (P < .05).ConclusionsLoss of unilateral peripheral input in SSD is associated with spatial reorganization of the auditory cortex in both hemispheres. This change in central auditory functional organization may in turn lead to higher order hearing deficits that rely on interhemispheric processing. Hearing optimization in the only hearing ear may require remediation of both spatial and temporal central auditory changes in SSD.Level of EvidenceNA Laryngoscope, 126:2785-2791, 2016