Augmentation Pressure Is Influenced by Ventricular Contractility/Relaxation Dynamics Novel Mechanism of Reduction of Pulse Pressure by Nitrates
Augmentation Pressure Is Influenced by Ventricular Contractility/Relaxation Dynamics Novel Mechanism of Reduction of Pulse Pressure by Nitrates
复制标题
DOI：
10.1161/hypertensionaha.113.02955
复制
发表时间：
2014-05-01
期刊：
影响因子：
8.3
通讯作者：
Chowienczyk, Phil
中科院分区：
文献类型：
--
作者：
Fok, Henry;Guilcher, Antoine;Chowienczyk, Phil
加压（AP），即主动脉压力在第一收缩期肩部上方的增加，被认为主要由压力波反射决定，但可能受到心室射血特征的影响。我们试图确定硝酸甘油（NTG）选择性还原AP的机制。30例受试者（11例女性，年龄61 +/- 13岁[mean +/- SD]）在心导管插入时同时测量主动脉压力和血流，进行波强度分析，并分别计算心室和动脉树产生的AP正向和反向分量。测量分别在基线和NTG给予全身（800 g舌下，n=20）和局部冠状动脉内输注（1 g/min, n=10）后进行。全身性NTG对第一肩压无显著影响，但可使增强（和中心脉压）降低12.8 +/- 3.1 mm Hg (P
Augmentation pressure (AP), the increment in aortic pressure above its first systolic shoulder, is thought to be determined mainly by pressure wave reflection but could be influenced by ventricular ejection characteristics. We sought to determine the mechanism by which AP is selectively reduced by nitroglycerin (NTG). Simultaneous measurements of aortic pressure and flow were made at the time of cardiac catheterization in 30 subjects (11 women; age, 61 +/- 13 years [mean +/- SD]) to perform wave intensity analysis and calculate forward and backward components of AP generated by the ventricle and arterial tree, respectively. Measurements were made at baseline and after NTG given systemically (800 g sublingually, n=20) and locally by intracoronary infusion (1 g/min; n=10). Systemic NTG had no significant effect on first shoulder pressure but reduced augmentation (and central pulse pressure) by 12.8 +/- 3.1 mm Hg (P