Oxidative stress, inflammation and disease activity biomarkers in lupus nephropathy
Oxidative stress, inflammation and disease activity biomarkers in lupus nephropathy
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DOI：
10.1177/0961203320904784
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发表时间：
2020-02-16
期刊：
影响因子：
2.6
通讯作者：
Arriaga, S. M. M.
中科院分区：
文献类型：
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作者：
Bona, N.;Pezzarini, E.;Arriaga, S. M. M.
狼疮肾病是系统性红斑狼疮的一种严重而常见的并发症。在这里，我们评估了狼疮性肾炎患者的氧化应激、炎症和疾病活动性的生物标志物。研究对象包括34例活动性狼疮性肾炎、31例非活动性狼疮性肾炎和20例无肾损害（非狼疮性肾炎）的狼疮性肾炎患者。评估氧化应激生物标志物丙二醛、氧化至总谷胱甘肽、过氧化氢酶、超氧化物歧化酶和总抗氧化状态，以及炎症生物标志物CRP、白细胞介素6和单核细胞化学引诱蛋白1。评估肾小管疾病生物标志物中性粒细胞明胶酶相关脂钙蛋白和β 2微球蛋白，以及经典疾病活动性生物标志物尿蛋白/肌酐比值、抗dsdna、抗c1q抗体和补体蛋白C3和C4。活动期狼疮性肾炎患者与非活动期狼疮性肾炎患者、活动期狼疮性肾炎患者与非狼疮性肾炎患者除过氧化氢酶、超氧化物歧化酶和白细胞介素6外，所有评估的生物标志物均有显著差异（P < 0.05）。活动性狼疮性肾炎患者的氧化还原状态不平衡，这可能涉及肾小球基底膜的脂质过氧化，从而改变其完整性，并可能影响这些患者的肾小管功能。
Lupus nephropathy is a severe and frequent complication of systemic lupus erythematosus. Here, we assessed the biomarkers of oxidative stress, inflammation and disease activity in patients with lupus nephritis. Thirty-four patients with active lupus nephritis, 31 patients with inactive lupus nephritis and 20 lupus patients without renal damage (non-lupus nephritis) were studied. Oxidative stress biomarkers malonyldialdehyde, oxidized-to-total glutathione, catalase, superoxide dismutase and total antioxidant status were assessed, as well as inflammation biomarkers CRP, interleukin 6 and monocyte chemoattractant protein 1. Renal tubular disease biomarkers neutrophil gelatinase-associated lipocalin and beta 2-microglobulin were assessed, together with the classic disease activity biomarkers urinary protein/creatinine ratio, anti-dsDNA, anti-C1q antibody and complement proteins C3 and C4. Significant differences were found between active lupus nephritis and inactive lupus nephritis patients and between active lupus nephritis and non-lupus nephritis patients for all the assessed biomarkers (P < 0.05), except for catalase, superoxide dismutase and interleukin 6. There is an imbalance in the redox status in active lupus nephritis patients that would be involved in lipid peroxidation of the glomerular basal membrane that would alter its integrity and could also affect renal tubular function in these patients.