Critical contribution of the interleukin-6/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis.
Critical contribution of the interleukin-6/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis.
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白细胞介素 6/信号转导器和转录 3 轴激活剂对系统性硬化症相关血管病变的关键贡献。
DOI：
10.1111/1346-8138.13827
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Sato S.
中科院分区：
文献类型：
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作者：
Taniguchi T;Asano Y;Fukasawa T;Yoshizaki A;Sato S.
反映了白细胞介素（IL）-6在系统性硬化症（SSc）中的关键作用，托珠单抗（一种抗IL-6受体抗体）目前正在进行针对该疾病皮肤硬化症的全球III期试验。我们在此证明，IL-6/信号转导和转录激活因子3轴在SSc患者皮损皮肤中的各种细胞类型中广泛激活，无论疾病亚型如何，尤其是在内皮细胞中。重要的是，12个月一次的托珠单抗输注改善了弥漫性皮肤SSc患者的甲襞毛细血管变化以及皮肤硬化。目前的研究结果表明，托珠单抗对SSc血管病变具有潜在的疾病改善作用。
Reflecting the critical role of interleukin (IL)‐6 in systemic sclerosis (SSc), tocilizumab, an anti‐IL‐6 receptor antibody, is currently under a global phase III trial against skin sclerosis of this disease. We here demonstrate that the IL‐6/signal transducer and activator of transcription 3 axis is broadly activated in various cell types in the lesional skin of SSc patients irrespective of disease subtypes, especially in endothelial cells. Importantly, 12 monthly infusions of tocilizumab improved nailfold capillary changes as well as skin sclerosis in a patient with diffuse cutaneous SSc. The present findings suggest a potential disease‐modifying effect of tocilizumab on SSc vasculopathy.