L-shell x-ray fluorescence measurements of lead in bone: theoretical considerations
L-shell x-ray fluorescence measurements of lead in bone: theoretical considerations
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DOI：
10.1088/0031-9155/47/3/310
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发表时间：
2002-02-07
影响因子：
3.5
通讯作者：
Todd, AC
中科院分区：
文献类型：
--
作者：
Todd, AC
本文综述了有关铅l壳x射线在体内测量骨中铅的几个理论问题：衰减校正方法、测量不确定度的贡献、干扰、骨取样深度和信号强度。预测骨铅浓度及其测量不确定度都受选择线性衰减系数的影响，该系数用于校正上覆组织。测量不确定度还受到身体组成的个体差异、超声测量上覆组织厚度的方法不确定度以及LXRF位置与超声测量位置之间的差异的影响。As Kalpha对Pb - α x射线的干扰被夸大了，可能可以忽略不计；非骨组织中铅的干扰可能不会。对于K和L x射线荧光的不同骨成分，计算了获得信号的骨深度和信号强度的粗略估计。
This paper reviews several theoretical considerations pertinent to the use of lead L-shell x-rays for the in vivo measurement of lead in bone: the method of correcting for attenuation, the contributions to the measurement uncertainty, interferences, the depth of bone sampled and the signal strength. Both the predicted bone lead concentration and the measurement uncertainty therein are influenced by the choice of linear attenuation coefficient with which to correct for overlying tissue. Measurement uncertainty is also influenced by inter-individual variability in body composition, methodological uncertainty in the ultrasound measurement of overlying tissue thickness and discrepancy between the site of LXRF and the site of ultrasound measurement. Interference with the Pb Lalpha x-rays by As Kalpha has been overstated and is probably negligible; interference from lead in non-bone tissues may not be. The depth of bone from which the signal is obtained and a crude estimate of signal strength are calculated for different bone compositions for both K and L x-ray fluorescence.