MITOCHONDRIAL CALCIUM SPIKING - A TRANSDUCTION MECHANISM-BASED ON CALCIUM-INDUCED PERMEABILITY TRANSITION INVOLVED IN CELL CALCIUM SIGNALING
MITOCHONDRIAL CALCIUM SPIKING - A TRANSDUCTION MECHANISM-BASED ON CALCIUM-INDUCED PERMEABILITY TRANSITION INVOLVED IN CELL CALCIUM SIGNALING
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DOI：
10.1016/0014-5793(94)00615-6
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发表时间：
1994-07-11
期刊：
影响因子：
3.5
通讯作者：
HOLMUHAMEDOV, EL
中科院分区：
文献类型：
--
作者：
ICHAS, F;JOUAVILLE, LS;HOLMUHAMEDOV, EL
我们报道了可逆的Ca2+诱导的Ca2+释放从线粒体，这采取Ca2+尖峰的形式。线粒体Ca2+尖峰是一个全有或无的过程，其阈值依赖于作为刺激的Ca2+脉冲的频率和幅度。这种尖峰依赖于线粒体渗透性过渡孔的瞬时操作，并以阈值依赖的方式启动-在渗透性细胞中由肌醇三磷酸介导的Ca2+反应。有证据表明，线粒体Ca2+诱导的Ca2+释放有助于肌醇三磷酸介导的完整细胞中的Ca2+反应。
We report reversible Ca2+-induced Ca2+ release from mitochondria, which takes the form of Ca2+ spikes. Mitochondrial Ca2+ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca2+ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated - in a threshold-dependent manner - with inositol-triphosphate-mediated Ca2+ responses in permeabilized cells. Evidence that mitochondrial Ca2+-induced Ca2+ release contributes to inositol-triphosphate-mediated Ca2+ responses in intact cells is also reported.