A Facile Construction of Bi- or Tricyclic Skeletons by Nickel-Catalyzed Stereoselective Cyclization of Alkynylcycloalkanone
A Facile Construction of Bi- or Tricyclic Skeletons by Nickel-Catalyzed Stereoselective Cyclization of Alkynylcycloalkanone
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DOI：
10.1021/ol101329d
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发表时间：
2010-08-06
期刊：
影响因子：
5.2
通讯作者：
Sato, Yoshihiro
中科院分区：
文献类型：
--
作者：
Saito, Nozomi;Sugimura, Yasuyuki;Sato, Yoshihiro
在镍的催化下，在Et(3)SiH存在下，以NHC为配体的分子内环化反应以立体选择性的方式生成了各种碳环和杂环。该反应将通过形成氧镍环进行，然后与硅烷进行Sigma键的歧化反应，得到双环或三环化合物。
A nickel-catalyzed intramolecular cyclization of alkynylalkanone in the presence of Et(3)SiH using an NHC ligand produced various carbo- and heterocycles In a stereoselective manner. The reaction would proceed via formation of oxanickelacycle followed by sigma-bond metathesis with silane to give a bi- or tricyclic compound.