Efficient reconstruction method for L1 regularization in fluorescence molecular tomography
Efficient reconstruction method for L1 regularization in fluorescence molecular tomography
复制标题
荧光分子断层扫描L1正则化的高效重建方法
DOI：
10.1364/ao.49.006930
复制
发表时间：
2010-12-20
期刊：
影响因子：
1.9
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Han, Dong;Yang, Xin;Tian, Jie
荧光分子断层成像（FMT）是一种很有前途的小动物活体成像技术。在本文中，荧光源的稀疏性被认为是先验信息，并通过结合L1正则化提升。然后提出了一种基于分段正交匹配追踪的重建算法，将FMT问题转化为基追踪问题。为了评估这种方法，我们将其与基于迭代收缩的L1正则化算法进行比较。数值模拟和物理实验表明，该方法可以获得相当甚至略好的结果。更重要的是，在这些实验中，所提出的方法至少快2个数量级，这使得它成为一种实用的重建算法。(C)2010年美国光学学会
Fluorescence molecular tomography (FMT) is a promising technique for in vivo small animal imaging. In this paper, the sparsity of the fluorescent sources is considered as the a priori information and is promoted by incorporating L1 regularization. Then a reconstruction algorithm based on stagewise orthogonal matching pursuit is proposed, which treats the FMT problem as the basis pursuit problem. To evaluate this method, we compare it to the iterated-shrinkage-based algorithm with L1 regularization. Numerical simulations and physical experiments show that the proposed method can obtain comparable or even slightly better results. More importantly, the proposed method was at least 2 orders of magnitude faster in these experiments, which makes it a practical reconstruction algorithm. (C) 2010 Optical Society of America