Enhanced bone ingrowth into hydroxyapatite with interconnected pores by electrical polarization
Enhanced bone ingrowth into hydroxyapatite with interconnected pores by electrical polarization
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DOI：
10.1016/j.biomaterials.2006.07.007
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发表时间：
2006-11-01
期刊：
影响因子：
14
通讯作者：
Yamashita, Kimihiro
中科院分区：
文献类型：
--
作者：
Itoh, Soichiro;Nakamura, Satoshi;Yamashita, Kimihiro
羟基磷灰石（HA）陶瓷被用作修复受损/去除骨的植入物，负或正电极化分别在体内增强成骨细胞和降低破骨细胞活性。我们比较了电极化和非电极化的具有互连孔的HA（IPHA）植入物促进骨生长的能力。将极化或未处理的IPHA植入兔右侧或左侧股骨髁（每组N = 10），并在植入后3周和6周进行组织学检查，包括成骨细胞和破骨细胞的酶染色。我们观察到极化种植体中骨长入改善，成骨细胞活性增加，早在术后3周就发生了完全骨渗透到极化种植体中。相比之下，非极化种植体在术后6周未完全骨化。此外，与带负电或不带电区域相比，带正电的植入区域破骨细胞活性降低。我们提出了两种不同的模型来解释这些观察结果。(c)2006爱思唯尔有限公司保留所有权利。
Hydroxyapatite (HA) ceramics are used as implants to repair damaged/removed bone, and negative or positive electrical polarization enhances osteoblast and decreases osteoclast activity, respectively, in vivo. We compared the ability of electrically polarized and non-polarized HA with interconnected pores (IPHA) implants to promote bone growth. Polarized or non-treated IPHAs were implanted into the right or left femoral condyle of rabbits (N = 10 in each group), and we performed histological examination, including enzymatic staining for osteoblasts and osteoclasts, 3 and 6 weeks after implantation. We observed improved bone ingrowth and increased osteoblast activity in polarized implants with complete bone penetration into polarized implants occurring as early as 3 weeks after surgery. In contrast, non-polarized implants were not fully ossified at 6 weeks after surgery. Furthermore, positively charged implant regions had decreased osteoclast activity compared to negatively charged or uncharged regions. We propose two different models to explain these observations. (c) 2006 Elsevier Ltd. All rights reserved.