EFFECT OF DEFENSIN ON PLATELET FUNCTIONAL-ACTIVITY
EFFECT OF DEFENSIN ON PLATELET FUNCTIONAL-ACTIVITY
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DOI：
10.1007/bf00846346
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发表时间：
1993-01-01
影响因子：
0.7
通讯作者：
KUBATIEV, AA
中科院分区：
文献类型：
--
作者：
ASHMARIN, IP;TKACHENKO, SB;KUBATIEV, AA
研究了人中性粒细胞防御素对人血小板功能的影响。防御素（0.1-40微克/毫升）不促进血小板聚集。防御素降低血小板对ADF、胶原或凝血酶的聚集反应。防御素显著降低凝血酶和胶原诱导的血小板聚集过程中释放的ATP水平和丙二醛的产生。这些数据表明，防御素参与血小板和中性粒细胞之间的细胞-细胞相互作用，抵消激动剂诱导的血小板活化。
The effects of human neutrophil peptide defensin were studied on human platelet function. Defensin (0.1-40 micrograms/mL) did not promote platelet aggregation. Defensin decreased platelet aggregation responses to ADF, collagen or thrombin. Defensin significantly lessened ATP level, released during platelet aggregation, and malondialdehyde production, induced by thrombin and collagen. These data reveal that defensins involve in cell-cell interaction between platelets and neutrophils counteracting agonist-induced platelet activation.