Hand Hygiene Practices and the Risk of Human Coronavirus Infections in a UK Community Cohort.
Hand Hygiene Practices and the Risk of Human Coronavirus Infections in a UK Community Cohort.
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DOI：
10.12688/wellcomeopenres.15796.2
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发表时间：
2020
影响因子：
--
通讯作者：
Fragaszy EB
中科院分区：
文献类型：
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作者：
Beale S;Johnson AM;Zambon M;Flu Watch Group;Hayward AC;Fragaszy EB
背景：手部卫生可能会减缓COVID-19在社区环境中的传播;然而，经验证据有限。鉴于有报道称COVID-19和季节性冠状病毒的传播机制相似，我们调查了手部卫生是否影响季节性冠状病毒感染的风险。 方法：数据来自英格兰流感观察研究的三个连续冬季队列（2006-2009年）。 参与者（n=1633）提供了手部卫生行为的基线估计。使用RT-PCR从鼻拭子中鉴定冠状病毒感染。Poisson混合模型估计了手部卫生对冠状病毒疾病个人风险的影响，未调整和调整年龄和医疗保健工作者身份的混杂因素。 结果如下：中等频率洗手（每天6-10次）预测冠状病毒感染的个人风险较低（调整后的发病率比（aIRR）=0.64，p=0.04）。没有证据表明洗手的剂量反应效应，更高水平的手部卫生（每天>10次）的结果不显著（aIRR =0.83，p=0.42）。 结论：这是第一个经验证据表明，定期洗手可以降低获得季节性冠状病毒感染的个人风险。这些发现支持在当前COVID-19大流行的背景下围绕洗手的保护作用发出明确的公共卫生信息。
Background: Hand hygiene may mitigate the spread of COVID-19 in community settings; however, empirical evidence is limited. Given reports of similar transmission mechanisms for COVID-19 and seasonal coronaviruses, we investigated whether hand hygiene impacted the risk of acquiring seasonal coronavirus infections. Methods: Data were drawn from three successive winter cohorts (2006-2009) of the England-wide Flu Watch study. Participants ( n=1633) provided baseline estimates of hand hygiene behaviour. Coronavirus infections were identified from nasal swabs using RT-PCR. Poisson mixed models estimated the effect of hand hygiene on personal risk of coronavirus illness, both unadjusted and adjusted for confounding by age and healthcare worker status. Results: Moderate-frequency handwashing (6-10 times per day) predicted a lower personal risk of coronavirus infection (adjusted incidence rate ratio (aIRR) =0.64, p=0.04). There was no evidence for a dose-response effect of handwashing, with results for higher levels of hand hygiene (>10 times per day) not significant (aIRR =0.83, p=0.42). Conclusions: This is the first empirical evidence that regular handwashing can reduce personal risk of acquiring seasonal coronavirus infection. These findings support clear public health messaging around the protective effects of hand washing in the context of the current COVID-19 pandemic.