Adrenal and thyroid axis function in preterm ventilated baboons.
Adrenal and thyroid axis function in preterm ventilated baboons.
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早产通气狒狒的肾上腺和甲状腺轴功能。
DOI：
10.1159/000068922
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Seidner,StevenR
中科院分区：
文献类型：
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作者：
Jobe,AlanH;Scott,SusanM;Polk,DanielH;Seidner,StevenR
皮质醇和甲状腺激素对正常的胎儿发育和新生儿过渡至关重要，早产后基线值和刺激试验异常。为了评估皮质醇和甲状腺素（T4）反应不受与人类早产相关的未控制产前事件的影响，我们在标准剂量促肾上腺皮质激素（ACTH）和促肾上腺皮质激素释放激素（CRH）刺激试验后测量了皮质醇和T4，以及在妊娠125天的狒狒中进行的高剂量CRH和促甲状腺激素释放激素刺激试验，（期限186天）。对动物进行表面活性剂处理并通气长达14天。一些胎仔暴露于胎仔或母体β-雌二醇，一些新生儿在出生后接受10 µg/kg T4治疗9天。到第5天，基线皮质醇水平处于30-60 µg/dl的应激范围内。皮质醇并没有增加一致，直到第11天，以响应高剂量的CRH或ACTH。出生后9天的T4治疗抑制皮质醇反应和随后的基线T4水平。下丘脑-垂体-肾上腺（HPA）轴对标准剂量刺激试验无反应，直到早产狒狒11日龄，表明HPA不成熟。
Cortisol and thyroid hormones are critical to normal fetal development and neonatal transition, and baseline values and stimulation tests are abnormal after preterm birth. To evaluate cortisol and thyroxine (T4) responses that are not influenced by uncontrolled antenatal events associated with human preterm labor, we measured cortisol and T4after standard-dose adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) stimulation tests, as well as high-dose CRH and thyrotropin-releasing hormone stimulation tests in baboons that were delivered for 3 separate protocols at 125 days of gestation (term is 186 days). The animals were surfactant treated and ventilated for up to 14 days. Some fetuses were exposed to fetal or maternal betamethasone, and some newborns were treated with 10 µg/kg T4for 9 days after birth. Baseline cortisol levels were in a stress range of 30–60 µg/dl by day 5. Cortisol did not increase consistently until day 11 in response to a high CRH dose or ACTH. T4treatment for 9 days after birth suppressed the cortisol responses and subsequent baseline T4levels. The hypothalamic-pituitary-adrenal (HPA) axis was unresponsive to standard dose stimulation tests until 11 days of age in preterm baboons, indicating HPA immaturity.