BEHAVIOR OF HYPOCHLORITE AND OF CHLORAMINE-T SOLUTIONS IN CONTACT WITH NECROTIC AND NORMAL TISSUES IN VIVO.
BEHAVIOR OF HYPOCHLORITE AND OF CHLORAMINE-T SOLUTIONS IN CONTACT WITH NECROTIC AND NORMAL TISSUES IN VIVO.
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DOI：
10.1084/jem.27.5.627
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发表时间：
1918-05-01
期刊：
影响因子：
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通讯作者：
Taylor HD
中科院分区：
文献类型：
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作者：
Austin JH;Taylor HD
1. Dakin的次氯酸盐溶液的氯浓度的下降在与坏死组织接触时比与正常组织接触时更快。2.氯胺-T溶液用于坏死组织时氯浓度的下降非常轻微，用于正常组织时可忽略不计。3.次氯酸盐溶液对组织的作用导致坏死组织、毛发、上皮鳞片、凝固血清等颗粒的分离，并且这些物质在至少17小时的时间内逐渐消化。4.次氯酸盐溶液的氯浓度的下降直到颗粒完全溶解才完成。5. 2%的氯胺-T溶液没有与次氯酸盐溶液所表现出的腐蚀作用相比较的腐蚀作用。6.重复暴露于这三种溶液表明次氯酸盐溶液对坏死组织的清洁能力更上级。7.次氯酸盐溶液对正常家兔皮肤的刺激性明显大于氯胺T溶液和碱性对照液。8.因此，刺激性作用一定是由于容易获得的氯。
1. The fall in chlorine concentration of Dakin's hypochlorite solution is more rapid in contact with necrotic than in contact with normal tissue. 2. The fall in chlorine concentration of chloramine-T solution is very slight when applied to necrotic tissue and is negligible when applied to normal tissue. 3. The action of the hypochlorite solution on tissue results in the separation of particles of necrotic tissue, hair, epithelial scales, coagulated serum, etc., and a gradual digestion of these substances, taking place over a period of at least 17 hours. 4. The fall in the chlorine concentration of the hypochlorite solution is not complete until the particles are completely dissolved. 5. Chloramine-T solution, 2 per cent, has no erosive effect comparable with that exhibited by the hypochlorite solution. 6. Repeated exposures to the three solutions show the hypochlorite solution to be superior in its cleansing ability on necrotic tissue. 7. The hypochlorite solution is much more irritating to normal rabbit skin than chloramine-T solution or the alkaline control solution. 8. Therefore, the irritating effects must be due to the readily available chlorine.