Individual variation in human motor-sensory (rolandic) cortex
Individual variation in human motor-sensory (rolandic) cortex
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DOI：
10.1097/wnp.0b013e31803bb59a
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发表时间：
2007-06-01
影响因子：
2.4
通讯作者：
Ojemann, George A.
中科院分区：
文献类型：
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作者：
Farrell, Donald F.;Burbank, Nicole;Ojemann, George A.
雄辩皮层通常使用多种技术来识别，包括直接电刺激来识别运动感觉、语言和记忆皮层，体感诱发电位来识别运动感觉皮层。识别这些皮层区域以防止在神经外科手术过程中造成损伤是很重要的。采用体感诱发电位和直接电刺激对70例长期植入硬脑膜下网格的癫痫患者进行回顾性研究。与体感诱发电位相比，直接电刺激运动感觉皮层引起的反应面积更大。使用这两种技术可以识别出大量的个体差异。本研究的结果支持了先前的结论，即放弃运动感觉皮层的小块体解剖学（点对点表征）的概念，并取代了运动感觉皮层的功能嵌合体模型。在人类运动-感觉皮层中发现的个体差异将需要继续进行“大脑绘图”，以识别有功能的皮层，以便在新皮层神经外科手术中保留这些重要区域。
Eloquent cortex is generally identified using a variety of techniques including direct electrical stimulation to identify motorsensory, language, and memory cortex and somatosensory evoked potentials to identify motor-sensory cortex. It is important that these areas of cortex be identified so as to prevent damage during the course of neurosurgical procedures. Seventy epilepsy patients undergoing evaluation for epilepsy surgery with chronically implanted subdural grids were retrospectively studied using both somatosensory evoked potentials and direct electrical stimulation. Direct electrical stimulation of motor-sensory cortex elicited responses over a larger area than did somatosensory evoked potentials. A great deal of individual variation was identified using both techniques. The results presented here support previous conclusions that the concept of homunculus somatotopy (point to point representation) of the motor-sensory cortex be abandoned and that of functional mosaicism of the motorsensory cortex replace the earlier model. The individual variation found in the human motor-sensory cortex will require a continuation of "brain mapping" to identify eloquent cortex so that these vital areas will be spared during neocortical neurosurgical procedures.