Effects of folic acid supplementation on hearing in older adults - A randomized, controlled trial
Effects of folic acid supplementation on hearing in older adults - A randomized, controlled trial
复制标题
DOI：
10.7326/0003-4819-146-1-200701020-00003
复制
发表时间：
2007-01-02
影响因子：
39.2
通讯作者：
Kok, Frans J.
中科院分区：
文献类型：
--
作者：
Durga, Jane;Verhoef, Petra;Kok, Frans J.
背景：听力损失是老年人常见的慢性疾病。低叶酸水平与听力下降有关。目的：确定补充叶酸是否能减缓年龄相关性听力损失。设计：2000年9月至2004年12月进行的双盲、随机、安慰剂对照试验。地点：荷兰。参与者：从市政和血库登记处招募了728名血浆总同型半胱氨酸浓度≥ 13 μ mol/L的老年男性和女性，血清和维生素B-筛选时有12种浓度≥ 200 pmol/L，且无中耳功能障碍、单侧听力损失或与衰老无关的病理性耳部疾病。干预：每日口服叶酸（800 μ g）或安慰剂补充3年。听力阈值的3年变化，评估为低听力组双耳纯音气导阈值的平均值结果：初始中位听阈低频为11.7 dB（四分位距7.5 ~ 17.5 dB），高频为34.2 dB（四分位距22.5 ~ 50.0 dB）。16名参与者（2%）失访。3年后，叶酸组的低频阈值增加了1.0 dB（95% CI，0.6至1.4 dB），安慰剂组增加了1.7 dB（CI，1.3至2.1 dB）（差异，-0.7 dB [CI，-1.2至-0.1 dB]; P = 0.020）。补充叶酸并没有影响听力高频的下降。局限性：基于血清同型半胱氨酸浓度的严格参与标准限制了外推至一般人群。研究期间，荷兰禁止在食物中添加叶酸，因此参与者的基线叶酸水平约为美国的一半。S. population.Conclusions:在一个没有叶酸强化食品的国家，叶酸补充剂减缓了与老龄化相关的语言频率听力下降。这种效果需要确认，特别是在叶酸强化计划国家的人群中。
Background: Age-related hearing loss is a common chronic condition of elderly persons. Low folate status has been associated with poor hearing.Objective: To determine whether folic acid supplementation slows age-related hearing loss.Design: Double-blind, randomized, placebo-controlled trial conducted from September 2000 to December 2004.Setting: The Netherlands.Participants: 728 older men and women recruited from municipal and blood bank registries with plasma total homocysteine concentrations 13 mu mol/L or greater serum and vitamin B-12 concentrations 200 pmol/L or greater at screening, and no middle ear dysfunction, unilateral hearing loss, or pathologic ear conditions unrelated to aging.Intervention: Daily oral folic acid (800 mu g) or placebo supplementation for 3 years.Measurements: 3-year change in hearing thresholds, assessed as the average of the pure-tone air conduction thresholds of both ears of the low (0.5-kHz, 1-kHz, and 2-kHz) and high (4-kHz, 6-kHz, and 8-kHz) frequencies.Results: Initial median hearing thresholds were 11.7 dB (interquartile range, 7.5 to 17.5 dB) for low frequencies and 34.2 dB (interquartile range, 22.5 to 50.0 dB) for high frequencies. Sixteen participants (2%) were lost to follow-up. After 3 years, thresholds of the low frequencies increased by 1.0 dB (95% CI, 0.6 to 1.4 dB) in the folic acid group and by 1.7 dB (CI, 1.3 to 2.1 dB) in the placebo group (difference, -0.7 dB [CI, -1.2 to -0.1 dB]; P = 0.020). Folic acid supplementation did not affect the decline in hearing high frequencies. Limitations: The strict criterion for participation on the basis of serum homocysteine concentrations limits extrapolation to the general population. Folic acid fortification of food was prohibited in the Netherlands during the study, so baseline folate levels in participants were about half of those found in the U. S. population.Conclusions: Folic acid supplementation slowed the decline in hearing of the speech frequencies associated with aging in a population from a country without folic acid fortification of food. The effect requires confirmation, especially in populations from countries with folic acid fortification programs.