Training-induced functional activation changes in dual-task processing: An fMRI study
Training-induced functional activation changes in dual-task processing: An fMRI study
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DOI：
10.1093/cercor/bhj137
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发表时间：
2007-01-01
期刊：
影响因子：
3.7
通讯作者：
Kramer, Arthur F.
中科院分区：
文献类型：
--
作者：
Erickson, Kirk I.;Colcombe, Stanley J.;Kramer, Arthur F.
虽然训练引起的大脑活动的变化已经被研究过了，但与执行功能相关的可塑性仍然研究不足。在这项研究中，我们研究了在需要执行控制的双重任务中，与训练相关的皮层活动变化。两个功能性磁共振成像（fMRI）会议，一个训练前，一个训练后，进行了对照组和训练组。使用感兴趣区域分析，我们检查了时间x组和时间x组x条件的相互作用，以隔离激活中的训练依赖性变化。我们发现，训练前参与双任务处理的大多数区域在训练后表现出激活减少。许多活动的减少与任务表现的改善有关。我们还发现，在双重任务条件下，训练组的背外侧前额叶皮层中有一个区域的激活增加，这也与提高的表现有关。这些结果进行了讨论，在有关的疗效的训练方案调节注意力和执行功能，双任务处理，和功能磁共振成像相关的可塑性。
Although training-induced changes in brain activity have been previously examined, plasticity associated with executive functions remains understudied. In this study, we examined training-related changes in cortical activity during a dual task requiring executive control. Two functional magnetic resonance imaging (fMRI) sessions, one before training and one after training, were performed on both a control group and a training group. Using a region-of-interest analysis, we examined Time x Group and Time x Group x Condition interactions to isolate training-dependent changes in activation. We found that most regions involved in dual-task processing before training showed reductions in activation after training. Many of the decreases in activation were correlated with improved performance on the task. We also found an area in the dorsolateral prefrontal cortex that showed an increase in activation for the training group for the dual-task condition, which was also correlated with improved performance. These results are discussed in relation to the efficacy of training protocols for modulating attention and executive functions, dual-task processing, and fMRI correlates of plasticity.