Autoimmune Hepatitis in the Asia-Pacific Area.
Autoimmune Hepatitis in the Asia-Pacific Area.
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亚太地区自身免疫性肝炎
DOI：
10.14218/jcth.2017.00032
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发表时间：
2018-03-28
影响因子：
3.6
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Wang QX;Yan L;Ma X
自身免疫性肝炎一直被认为是一种较为罕见的免疫性肝病，尤其是在亚太地区。虽然已经建立了诊断标准和免疫抑制治疗方案，但仍存在一些挑战。根据不同的介绍，对患有这种疾病的患者的个性化管理，包括那些慢性或急性严重发作，自身抗体阴性表型和肝硬化的患者，必须是描述性的。每个亚组患者应接受个体化治疗。本文综述了近年来自身免疫性肝炎的研究进展，主要集中在流行病学和遗传学、个性化诊断、个性化治疗策略、特殊亚群和结局等方面。文献中的大多数研究都是基于日本和中国的人口。
Abstract Autoimmune hepatitis has been considered as a relatively rare immunological liver disease, especially in the Asia-Pacific area. Although the diagnosis criteria and immunosuppressive treatment regimens have been established, there are still some challenges. According to the different presentations, the personalized management of patients who suffer from this disease, including those with chronic or acute severe onset, the autoantibody-negative phenotype and cirrhosis are necessarily descriptive. Each subgroup of patients should receive an individualized therapy. Here, we review the recent studies of autoimmune hepatitis, mainly focusing on the epidemiology and genetics, personalized diagnostics, individualized treatment strategies, special subgroups and outcomes. Most of the research in the literature is based on Japanese and Chinese populations.