A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids
A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids
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DOI：
10.1021/acs.joc.0c00312
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发表时间：
2020-04-03
影响因子：
3.6
通讯作者：
Sun, Zhankui
中科院分区：
文献类型：
--
作者：
Khan, Shah Nawaz;Zaman, Muhammad Kashif;Sun, Zhankui
A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.
