Detection of clinically silent brain lesions in [18F]FDG PET/CT study in oncological patients: analysis of over 10,000 studies.
Detection of clinically silent brain lesions in [18F]FDG PET/CT study in oncological patients: analysis of over 10,000 studies.
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DOI：
10.1038/s41598-021-98004-w
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发表时间：
2021-09-14
影响因子：
4.6
通讯作者：
Cholewiński W
中科院分区：
文献类型：
--
作者：
Pietrzak A;Marszałek A;Kunikowska J;Piotrowski T;Medak A;Pietrasz K;Wojtowicz J;Cholewiński W
该研究旨在表明，将大脑区域纳入标准2-脱氧-2-[18 F]氟代-d-葡萄糖正电子发射断层扫描/计算机断层扫描（[18 F]FDG PET/CT）研究方案可能会导致检测临床无症状脑肿瘤。我们回顾性分析了来自12，011名连续患者的10，378名患者，这些患者接受了躯干和大脑[18 F]FDG PET/CT扫描，考虑到该方法能够评估在我们机构诊断和治疗的脑肿瘤患者中未检出的脑肿瘤。在收集数据库时，我们遵循了入选标准：至少1年的随访，在我们机构收集的完整病史，组织病理学检查或其他可用于确认观察到的病变类型的研究，最重要的是-患者的医疗数据中没有报告脑部病变。在这项研究中，进行躯干和大脑[18F]FDG PET/CT成像有助于检测129例患者的临床无症状原发性和转移性脑肿瘤，以及24例研究病例中的良性病变，其中在检查前没有报告可疑的大脑发现。总之，将脑区纳入标准[18 F]FDG PET/CT方案可被认为有助于检测临床无症状的恶性和良性脑肿瘤。
The study aimed to show that including the brain region into the standard 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) study protocol may result in detecting clinically silent brain tumours. We retrospectively analyzed the group of 10,378 from the total of 12,011 consecutive patients who underwent the torso and brain [18F]FDG PET/CT scanning, considering an ability of the method to evaluate undetected before brain tumours in patients diagnosed and treated in our institution. While collecting the database, we followed the inclusion criteria: at least 1-year of follow-up, a full medical history collected in our institution, histopathologic examination or other studies available to confirm the type of observed lesion, and the most importantly—no brain lesions reported in the patients’ medical data. In this study, performing the torso and brain [18F]FDG PET/CT imaging helped to detect clinically silent primary and metastatic brain tumours in 129 patients, and the benign lesions in 24 studied cases, in whom no suspicious brain findings were reported prior to the examination. In conclusion, including the brain region into the standard [18F]FDG PET/CT protocol can be considered helpful in detecting clinically silent malignant and benign brain tumours.
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影响因子：
--
作者：
Shen B;Huang T;Sun Y;Jin Z;Li XF
通讯作者：
Li XF
影响因子：
4.6
作者：
Corroyer-Dulmont A;Valable S;Fantin J;Chatre L;Toutain J;Teulier S;Bazille C;Letissier E;Levallet J;Divoux D;Ibazizène M;Guillouet S;Perrio C;Barré L;Serres S;Sibson NR;Chapon F;Levallet G;Bernaudin M
通讯作者：
Bernaudin M
影响因子：
--
作者：
Pope WB
通讯作者：
Pope WB
影响因子：
2.7
作者：
Albano, Domenico;Camoni, Luca;Bertagna, Francesco
通讯作者：
Bertagna, Francesco
影响因子：
1.3
作者：
Huston, Scott F.;Abdelmalik, Amir G.;Osman, Medhat M.
通讯作者：
Osman, Medhat M.