Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome.
Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome.
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DOI：
10.1186/1757-2215-7-31
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发表时间：
2014-03-14
影响因子：
4
通讯作者：
Delibasi T
中科院分区：
文献类型：
--
作者：
Karbek B;Ozbek M;Karakose M;Topaloglu O;Bozkurt NC;Cakır E;Aslan MS;Delibasi T
多囊卵巢综合征（PCOS）的女性患心血管疾病（CVD）的风险较高。已经发现和肽素对心肌缺血具有预测性。我们测试了和肽素是否是多囊卵巢综合征患者心血管疾病的预测因子，这些患者患心血管疾病的风险增加。这是一项在培训和研究医院进行的横断面对照研究。研究人群包括40名育龄PCOS妇女和43名对照组。我们评估了PCOS患者和对照组的人体测量和代谢参数、颈动脉内膜中层厚度和和肽素水平。PCOS组空腹胰岛素、胰岛素抵抗指数（HOMA-IR）、甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、游离睾酮、17-羟基孕酮、硫酸脱氢表雄酮（DHEAS）、颈动脉内膜中层厚度（CIMT）均显著高于对照组。PCOS组和肽素水平为12.61 ± 3.05pmol/L，对照组为9.60 ± 2.80pmol/L，两组比较有显著性差异（P < 0.001）。校正年龄和BMI后，和肽素水平与空腹胰岛素、游离睾酮水平、CIMT和HOM A-IR呈正相关，在胰岛素抵抗、高雄激素血症PCOS患者的代谢反应和动脉粥样硬化的发生发展中起重要作用。
Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Copeptin has been found to be predictive for myocardial ischemia. We tested whether copeptin is the predictor for CVD in PCOS patients, who have an increased risk of cardiovascular disease. This was a cross sectional controlled study conducted in a training and research hospital. The study population consisted of 40 reproductive-age PCOS women and 43 control subjects. We evaluated anthropometric and metabolic parameters, carotid intima media thickness and copeptin levels in both PCOS patients and control group. Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), free testosterone, 17-OH progesterone, Dehydroepiandrosterone sulfate (DHEAS), carotid intima media thickness (CIMT) levels were significantly higher in PCOS patients. Mean copeptin level was in 12.61 ± 3.05 pmol/L in PCOS patients while mean copeptin level was 9.60 ± 2.80 pmol/L in healthy control women (p < 0.001). After adjustment for age and BMI, copeptin level was positive correlated with fasting insulin, free testosterone levels, CIMT, and HOM A-IR. Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients.
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DOI：
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发表时间：
2006-11-01
影响因子：
5.5
作者：
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发表时间：
1972-01-01
期刊：
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影响因子：
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DOI：
10.1007/s00392-011-0343-y
发表时间：
2011-12
期刊：
Clinical research in cardiology : official journal of the German Cardiac Society
影响因子：
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作者：
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