INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION AND AXIAL LENGTH
INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION AND AXIAL LENGTH
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DOI：
10.1097/iae.0000000000000329
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发表时间：
2015-03-01
影响因子：
3.3
通讯作者：
Jonas, Jost B.
中科院分区：
文献类型：
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作者：
Hu, Qingjun;Liu, Guohua;Jonas, Jost B.
背景资料：为探讨眼内血管内皮生长因子（VEGF）的浓度与眼轴长度的关系，采用酶联免疫吸附试验（ELISA）检测经睫状体平坦部玻璃体切除术治疗特发性黄斑裂孔或视网膜前膜的患者玻璃体标本和血液标本中VEGF的浓度。通过生物测量法确定轴长。结果：该研究纳入了34名患有黄斑裂孔（n = 21）或视网膜前膜（n = 13）的患者，平均年龄为62.4 ± 10.5岁（范围：35-76岁），平均轴长为24.1 ± 1.8 mm（范围：21.0-29.1 mm）。玻璃体内VEGF浓度（平均值：71.0 +/- 63.2 pg/mL）显著（P < 0.001）低于血液中VEGF浓度（830 +/- 585 pg/mL）。这两个参数彼此显著相关（P = 0.04;相关系数r = 0.35）。玻璃体内VEGF浓度与性别（P = 0.25）或年龄（P = 0.48）无显著相关性。玻璃体内VEGF浓度越高，眼轴越短（P = 0.025; r = -0.39）或远视性屈光不正越高（P = 0.04; r = 0.35）。血浆VEGF浓度和血浆VEGF浓度与玻璃体内VEGF浓度的比值与眼轴长度（P = 0.89和P = 0.22）和屈光不正（P = 0.89和P = 0.26）均无显著相关性。这表明在眼内体积较大的眼睛中存在稀释效应，和/或在伴有玻璃体液化的轴向近视眼中VEGF的更新速率较快。
Background: To examine the intravitreal concentration of vascular endothelial growth factor (VEGF) in dependence of the axial length in eyes without intraocular neovascularization.Methods: The concentrations of VEGF in vitreous samples and blood samples of patients undergoing pars plana vitrectomy for treatment of idiopathic macular holes or epiretinal membranes were examined using enzyme-linked immunosorbent assay. Axial length was determined by biometry.Results: The study included 34 patients with macular holes (n = 21) or epiretinal membranes (n = 13) with a mean age of 62.4 +/- 10.5 years (range: 35-76 years) and a mean axial length of 24.1 +/- 1.8 mm (range: 21.0-29.1 mm). The intravitreal VEGF concentration (mean: 71.0 +/- 63.2 pg/mL) was significantly (P < 0.001) lower than the VEGF concentration in the blood (830 +/- 585 pg/mL). Both parameters were significantly associated with each other (P = 0.04; correlation coefficient r = 0.35). The intravitreal VEGF concentration was not significantly associated with gender (P = 0.25) or age (P = 0.48). A higher intravitreal VEGF concentration was significantly associated with a shorter axial length (P = 0.025; r = -0.39) or a higher hyperopic refractive error (P = 0.04; r = 0.35). Neither plasma concentration of VEGF nor the ratio of plasma VEGF concentrations to intravitreal VEGF concentration was significantly associated with axial length (P = 0.89 and P = 0.22, respectively) or with refractive error (P = 0.89 and P = 0.26, respectively).Conclusion: Intravitreal VEGF concentration decreased with increasing axial length. It suggests a diluting effect in eyes with larger intraocular volume and/or a faster turnover rate of VEGF in axially myopic eyes with vitreous liquefaction.