Total lesion glycolysis on FDG-PET/CT before salvage surgery predicts survival in laryngeal or pharyngeal cancer.
Total lesion glycolysis on FDG-PET/CT before salvage surgery predicts survival in laryngeal or pharyngeal cancer.
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DOI：
10.18632/oncotarget.24914
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发表时间：
2018-04-10
期刊：
影响因子：
--
通讯作者：
Hasegawa Y
中科院分区：
文献类型：
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作者：
Suzuki H;Tamaki T;Nishio M;Nakata Y;Hanai N;Nishikawa D;Koide Y;Hasegawa Y
我们研究了使用正电子发射断层扫描与计算机断层扫描相结合的 18F-氟脱氧葡萄糖摄取参数是否可以预测接受挽救手术的喉癌或咽癌患者的多种生存结果，包括无肺转移生存。将51例喉癌或咽癌患者抢救手术前的最大标准化摄取值、代谢肿瘤体积和总病灶糖酵解计算为18F-氟脱氧葡萄糖摄取参数。在单变量分析中，最大标准化摄取值≥22.8、代谢肿瘤体积≥2.4和总病灶糖酵解≥5.4与较短的总生存期显着相关。在根据临床分期进行调整的多变量分析中，总病变糖酵解≥5.4的患者表现出显着较短的总生存期。此外，在单变量分析中，总病灶糖酵解≥5.4与较短的疾病特异性生存期、无远处转移生存期和无肺转移生存期显着相关。总之，总病变糖酵解可以预测接受挽救手术的喉癌或咽癌患者的生存结果，包括肺转移。
We investigated whether 18F-fluorodeoxyglucose uptake parameters using positron emission tomography combined with computed tomography predicts several survival outcomes, including lung metastasis-free survival, in patients with laryngeal or pharyngeal cancer who underwent salvage surgery. The maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were calculated as 18F-fluorodeoxyglucose uptake parameters in 51 patients with laryngeal or pharyngeal cancer before salvage surgery. In univariate analysis, the maximum standardized uptake value ≥ 22.8, metabolic tumor volume ≥ 2.4, and total lesion glycolysis ≥ 5.4 were significantly correlated with shorter overall survival. In multivariate analysis with adjustment for clinical stage, patients with total lesion glycolysis ≥ 5.4 exhibited significantly shorter overall survival. Furthermore, total lesion glycolysis ≥ 5.4 was significantly correlated with shorter disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in univariate analysis. In conclusion, total lesion glycolysis predicts the survival outcomes including lung metastasis in patients with laryngeal or pharyngeal cancer who underwent salvage surgery.