Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.
Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.
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非编码 RNA 在结直肠癌中的调节作用
DOI：
10.3390/ijms160819886
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发表时间：
2015-08-21
影响因子：
5.6
通讯作者：
Wang ZN
中科院分区：
文献类型：
--
作者：
Wang J;Song YX;Ma B;Wang JJ;Sun JX;Chen XW;Zhao JH;Yang YC;Wang ZN
非编码RNA(NcRNAs)由于参与不同的生物过程而受到人们的关注。越来越多的研究表明，ncRNAs的突变或异常表达与包括癌症在内的各种疾病密切相关。本文对ncRNAs在结直肠癌中的异常调控进行了全面的综述，并对目前有关ncRNAs的研究结果进行了综述，包括长ncRNAs、microRNAs、小干扰RNAs、小核仁RNAs、小核仁RNAs、PIwi相互作用RNAs和环状RNAs。这些ncRNA在不久的将来可能成为治疗结直肠癌的新的生物标志物和靶点以及潜在的治疗工具，这一综述可能为进一步研究结直肠癌和选择有效的治疗靶点提供重要线索。
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.