Mechanisms of arrhythmias and conduction disorders in older adults.
Mechanisms of arrhythmias and conduction disorders in older adults.
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DOI：
10.1016/j.cger.2012.08.005
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Jahangir A
中科院分区：
文献类型：
--
作者：
Mirza M;Strunets A;Shen WK;Jahangir A
衰老与心律失常患病率增加有关，心律失常导致老年人发病率和死亡率升高。随着人口老龄化，心律失常，特别是心房颤动和室性心动过速的频率预计会增加，这将极大地影响医疗资源的利用。在人群中已经确定了与心律失常风险相关的几个临床因素，但老年人心律失常易感性增加的分子基础尚不完全清楚。因此，只有有限的治疗策略，针对病理生理过程，提高心脏易感性心律失常是可用的。结果研究的缺乏进一步加剧了这种情况，这些研究提供了证据，可以为老年人制定最佳管理指南。本文综述了心律失常的流行病学、与衰老相关的心脏结构和功能的变化，以及老年人心律失常发生的基础，了解这些对制定预防策略至关重要。
Aging is associated with an increased prevalence of cardiac arrhythmias, which contribute to higher morbidity and mortality in the elderly. The frequency of cardiac arrhythmias, particularly atrial fibrillation and ventricular tachyarrhythmia, is projected to increase as the population ages, greatly impacting health care resource utilization. Several clinical factors associated with the risk of arrhythmias have been identified in the population, yet the molecular bases for the increased predisposition to arrhythmogenesis in the elderly are not fully understood. Therefore, only limited therapeutic strategies directed at pathophysiological processes that enhance cardiac vulnerability to arrhythmias are available. This is further compounded by the paucity of outcome studies providing evidence on which optimal management guidelines can be formulated for the very elderly. This review highlights the epidemiology of cardiac dysrhythmias, changes incardiac structure and function associated with aging, and the basis for arrhythmogenesis in the elderly, the understanding of which is critical to formulate preventive strategies.
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影响因子：
10.8
作者：
Ausma, J;Coumans, WA;Borgers, M
通讯作者：
Borgers, M
DOI：
10.1016/s0735-1097(00)01133-5
发表时间：
2001-02-01
影响因子：
24
作者：
Brugada, J;Aguinaga, L;Sanz, G
通讯作者：
Sanz, G
DOI：
10.1111/j.1076-7460.2003.01751.x
发表时间：
2003-01-01
期刊：
The American journal of geriatric cardiology
影响因子：
--
作者：
Cheitlin, Melvin D
通讯作者：
Cheitlin, Melvin D
影响因子：
24
作者：
Chugh, SS;Jui, J;McAnulty, J
通讯作者：
McAnulty, J
影响因子：
10.8
作者：
Anyukhovsky, EP;Sosunov, EA;Rosen, MR
通讯作者：
Rosen, MR