Differential association of lead on length by zinc status in two-year old Mexican children.
Differential association of lead on length by zinc status in two-year old Mexican children.
复制标题
两岁墨西哥儿童中铅与锌状况的差异关联。
DOI：
10.1186/s12940-015-0086-8
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发表时间：
2015-12-30
期刊：
影响因子：
--
通讯作者：
Ettinger AS
中科院分区：
文献类型：
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作者：
Cantoral A;Téllez-Rojo MM;Levy TS;Hernández-Ávila M;Schnaas L;Hu H;Peterson KE;Ettinger AS
自1997年禁止含铅燃料以来，墨西哥的血铅水平有所下降，但其他来源仍然存在，包括使用铅釉陶瓷储存和制备食物。1-2岁儿童中几乎有30%缺锌。先前的研究已经证明了铅暴露和锌缺乏与身高的负相关性，但没有考虑联合效应。鉴于2012年学龄前儿童发育迟缓的患病率为13.6%，本研究的目的是评估血铅和儿童身高之间的关系是否因锌状况而改变。在墨西哥城进行的一项出生队列研究中，对291名24个月大的儿童进行了人体测量、膳食能量摄入、血清锌和血铅测定。儿童身高以适合该年龄组的卧位长度表示。血铅（BPb）和年龄别身高Z评分（LAZ）之间的关联进行了评估，使用的模型分层的锌状态测量的标准标准和调整：出生长度，母乳喂养的做法，能量摄入，母亲的身高和教育。中位（IQR）BPb为：0.17（0.12-0.26）μmol/L，17%的样本缺锌（<9.9 μmol/L）。在整个样本中，BPb与LAZ呈负相关（β =-0.19，p = 0.02）。在分层模型中，与锌充足组（β = −0.12，p = 0.22）相比，这种负相关性仅在缺锌组（β = −0.43，p = 0.04）中高出3倍以上，具有统计学显著性（BPb* 锌状态，相互作用p = 0.04）。锌充足是一个关键因素，可能会减弱铅对身高的负面影响。
Blood lead levels have decreased in Mexico since leaded fuel was banned in 1997, but other sources remain, including the use of lead-glazed ceramics for food storage and preparation. Zinc deficiency is present in almost 30 % of children aged 1–2 years. Previous studies have documented negative associations of both lead exposure and zinc deficiency with stature, but have not considered the joint effects. Given that the prevalence of stunting in pre-school aged children was 13.6 % in 2012, the aim of this study was to evaluate if the relationship between blood lead and child stature was modified by zinc status. Anthropometry, dietary energy intake, serum zinc and blood lead were measured in 291 children aged 24 months from an ongoing birth cohort study in Mexico City. Child stature was represented by recumbent length as appropriate for this age group. The association between blood lead (BPb) and length-for-age Z score (LAZ) was evaluated using a model stratified by zinc status measured by standard criteria and adjusted for: birth length, breastfeeding practices, energy intake, maternal height and education. Median (IQR) BPb was: 0.17 (0.12–0.26) μmol/L and 17 % of the sample had zinc deficiency (<9.9 μmol/L). BPb was inversely associated with LAZ in the overall sample (β = −0.19, p = 0.02). In stratified models, this negative association was more than three times higher and statistically significant only in the zinc deficient group (β = −0.43, p = 0.04) compared to the zinc replete group (β = −0.12, p = 0.22) (BPb*zinc status, p-for-interaction = 0.04). Zinc adequacy is a key factor that may attenuate the negative association of lead on stature in young children.