The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis.
The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis.
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DOI：
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发表时间：
2016-02
影响因子：
3.7
通讯作者：
K. Ting;S. Lester;E. Dunstan;C. Hill
中科院分区：
文献类型：
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作者：
K. Ting;S. Lester;E. Dunstan;C. Hill
在类风湿性关节炎（RA）中，不能根据单个变量在所有个体患者中测量疾病活动。疾病活动性评分（DAS）和DAS 28已被开发用于在日常临床实践以及在组和个体水平的临床试验中测量RA的疾病活动性。DAS/DAS 28是RA疾病活动的连续测量，其结合了来自肿胀关节、压痛关节、急性期反应和一般健康的信息。基于DAS的EULAR反应标准主要用于临床试验。EULAR反应标准将个体患者分类为无反应者、中度反应者或良好反应者，这取决于变化的幅度和达到的疾病活动水平。此外，早在90年代初，就已经制定了临界点来对缓解期患者进行分类。DAS 28被整合到几个电子病历和基于网络的系统中，用于日常临床实践中的监测目的。除此之外，它还与患者报告的结局指标（PROM）结合使用，以促进自我监测。
In rheumatoid arthritis (RA), disease activity cannot be measured in all individual patients according to a single variable. The Disease Activity Score (DAS) and the DAS28 have been developed to measure disease activity in RA both in daily clinical practice as well as in clinical trials on a group as well as individual level. The DAS/DAS28 is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and general health. The DAS-based EULAR response criteria were primarily developed to be used in clinical trials. The EULAR response criteria classify individual patients as non-, moderate, or good responders, dependent on the magnitude of change and level of disease activity reached. In addition, already in the early nineties, cut points were developed to categorise patients in remission. The DAS28 is incorporated in several electronic patient records and web-based systems for monitoring purposes in daily clinical practice. In addition to this, it is being used in combination with patient-reported outcome measures (PROMs) to facilitate self-monitoring.