Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii
Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii
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DOI：
10.1021/ol047641
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发表时间：
2005-02-03
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Morita, H;Ishioka, N;Kobayashi, J
从戴氏虎皮楠（Daphniphyllum teijsmanii）叶中分得两个新的生物碱化合物：虎皮楠定C（1）和D（2），其结构经波谱学鉴定。结合NOESY相关性和模拟分析，对I和2的相对立体化学进行了归属。瑞香素C（1）可提高NGF生物合成活性。
Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of I and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis.