Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part II: Arborizing Catheter for Convection-Enhanced Delivery in Tissue Phantoms
Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part II: Arborizing Catheter for Convection-Enhanced Delivery in Tissue Phantoms
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DOI：
10.15586/codon.glioblastoma.2017.ch18
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Rylander, Christopher G.
中科院分区：
文献类型：
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作者：
Elenes, Egleide Y.;Rylander, Christopher G.
对流增强给药(CED)是一种局部压力驱动的药物流入含有肿瘤组织的脑实质的过程，与扩散依赖疗法相比，输注的药物分布更广。然而，即使CED比简单的扩散法更有优势，靶向整个肿瘤和瘤周体积所需的大容量以前使用现有的导管也是无法实现的。我们提出了一种新型的多端口树枝状导管，专为改善药物在脑内的分布而设计。在使用琼脂糖脑模型进行的输液研究中，我们通过量化体积分散(V-d)和平均分配比(V-d：V-I)来评估树枝状导管的性能，并将结果与单口导管进行比较。实验分为三组：(1)单孔输液速度为1亩L/分钟；(2)单孔输液速度为7亩L/分钟；(3)7孔树枝状导管输液速度为1亩L/分钟/端口。树枝状导管组(10.47+/-1.07 cm(3))明显大于单孔导管组(2.36+/-0.21 cm(3)和5.14+/-0.56 cm(3))。树枝状导管的V-d：V-I在1 mU L/min时比单孔导管低37%，而在7 mU L/min时比单孔导管大100%。多端口树枝状导管产生最大的输液分布，这对CED是有利的；然而，它没有表现出最大的分布比率，可能是由于来自多个单独端口的分布体积重叠。
Convection-enhanced delivery (CED) is the process of local, pressure-driven flow of drugs into brain parenchyma containing tumor tissue, resulting in greater distribution of the infused drugs compared to diffusion-dependent therapies. Nevertheless, even with the advantage of CED over simple diffusion, the large volumes necessary to target entire tumors and peritumor volumes have been previously unachievable with currently available catheters. We present a novel, multiport, arborizing catheter designed specifically for improving drug distribution into the brain. We evaluated the performance of the arborizing catheter by quantifying volume dispersed (V-d) and mean distribution ratios (V-d:V-i) in infusion studies using agarose brain phantoms and compared results to a single-port catheter. Three experimental groups were evaluated: (i) single-port infusions at 1 mu L/min; (ii) single-port infusions at 7 mu L/min; and (iii) seven-port arborizing catheter infusions at 1 mu L/min/port. Significantly greater V-d was calculated for the arborizing catheter group (10.47 +/- 1.07 cm(3)) compared with the single-port catheter groups at the low-and high-flow rates (2.36 +/- 0.21 cm(3) and 5.14 +/- 0.56 cm(3)), respectively. V-d:V-i for the arborizing catheter was 37% lower than the single-port catheter at 1 mu L/min, but 100% greater than the single-port catheter at 7 mu L/min. The multiport, arborizing catheter produced the greatest distribution of the infusate, which would be advantageous for CED; however, it did not exhibit the greatest distribution ratio, likely due to overlapping distribution volumes from the multiple individual ports.