PREOPERATIVE CARCINOEMBRYONIC ANTIGEN AND SURVIVAL IN PATIENTS WITH COLORECTAL-CANCER
PREOPERATIVE CARCINOEMBRYONIC ANTIGEN AND SURVIVAL IN PATIENTS WITH COLORECTAL-CANCER
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DOI：
10.1002/bjs.1800710312
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发表时间：
1984-01-01
影响因子：
9.6
通讯作者：
MCARDLE, CS
中科院分区：
文献类型：
--
作者：
LEWI, H;BLUMGART, LH;MCARDLE, CS
对333例结直肠癌患者术前癌胚抗原（CEA）水平、原发肿瘤的可切除性、肿瘤扩散程度和术后生存率之间的关系进行了研究。接受“根治性”切除术的患者中有25%的CEA水平升高，而接受姑息治疗的患者中有五十六%的CEA水平升高。25%的Dukes B或C期肿瘤患者术前CEA水平升高，而D期肿瘤患者术前CEA水平升高的比例为70%。在接受根治性切除的患者中，术前CEA水平与随后的生存率之间没有相关性。在接受姑息性切除术的患者中，术前CEA水平升高与生存率低相关。虽然术前CEA水平反映了潜在疾病过程的程度，但术前CEA水平的估计在预测结直肠癌根治性切除术后预后不良的患者中价值有限。
The relationship between pre-operative levels of carcino-embryonic antigen (CEA), resectability of the primary tumour, the extent of tumour spread and subsequent survival was studied in 333 patients with colorectal cancer. Twenty-five per cent of patients undergoing ‘curative’ resection had elevated CEA levels compared with fifty-six per cent of patients receiving palliative treatment. Twenty-five per cent of patients with Dukes B or C tumours had elevated pre-operative CEA levels compared with seventy per cent of patients with stage D disease. In patients undergoing ‘curative’ resection there was no correlation between pre-operative CEA levels and subsequent survival. In patients undergoing palliative resection, elevated pre-operative CEA levels were associated with poor survival. Although pre-operative levels of CEA reflect the extent of the underlying disease process, estimations of pre-operative CEA levels are of limited value in predicting patients with a poor prognosis following curative resection for colorectal carcinoma.