Amygdala Functional Connectivity Is Associated With Emotion Regulation and Amygdala Reactivity in 4-to 6-Year-Olds
Amygdala Functional Connectivity Is Associated With Emotion Regulation and Amygdala Reactivity in 4-to 6-Year-Olds
复制标题
4 ~ 6岁儿童杏仁核功能连接与情绪调节和杏仁核反应有关
DOI：
10.1016/j.jaac.2020.01.024
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发表时间：
2021-01-01
影响因子：
13.3
通讯作者：
Petersen, Steven E.
中科院分区：
文献类型：
--
作者：
Gaffrey, Michael S.;Barch, Deanna M.;Petersen, Steven E.
目的：情绪失调是多种精神疾病的潜在危险因素。杏仁核-前额叶皮层（PFC）连接的改变一直与情绪失调有关。最近的数据表明，杏仁核PFC功能连接经历了一个长期的发展，与杏仁核的反应在幼儿期可能塑造这个展开的过程。关于杏仁核-PFC功能连接、杏仁核反应性和儿童早期情绪调节之间的关系知之甚少。这些信息对于理解早期情绪失调作为精神病理学的转诊断风险因素可能至关重要。本研究探讨了杏仁核功能连接，杏仁核反应性，情绪调节在学龄前儿童之间的关系。方法：共有66名药物幼稚4- 6岁的孩子参加了一项研究，在静息态功能磁共振成像（rs-fMRI）和父母报告的儿童情绪调节能力的数据进行了收集。结果：右侧杏仁核-内侧前额叶皮层（mPFC）功能连接与儿童情绪调节能力呈正相关，与儿童负面情绪和右侧杏仁核对面部表情的反应性呈负相关。右杏仁核-mPFC功能连接在统计上也介导了右杏仁核反应性增强与儿童负面情感增强之间的关系。结论：研究结果表明，幼儿期杏仁核-mPFC功能连接及其与杏仁核反应性和高度敏感发育时期情绪调节的关系，可能在早期情绪发展中发挥重要作用。这些结果告知情绪调节的神经发育生物学及其与精神病理学风险的潜在关系。
Objective: Emotion dysregulation has been suggested to be a potent risk factor for multiple psychiatric conditions. Altered amygdala-prefrontal cortex (PFC) connectivity has been consistently linked to emotion dysregulation. Recent data indicate that amygdala-PFC functional connectivity undergoes a prolonged period of development, with amygdala reactivity during early childhood potentially shaping this unfolding process. Little is known about the relationships between amygdala-PFC functional connectivity, amygdala reactivity, and emotion regulation during early childhood. This information is likely critical for understanding early emotion dysregulation as a transdiagnostic risk factor for psychopathology. The current study examined the relationships between amygdala functional connectivity, amygdala reactivity, and emotion regulation in preschoolers.Method: A total of 66 medication-naive 4- to 6-year-olds participated in a study where resting-state functional magnetic resonance imaging (rs-fMRI) and parent-reported child emotion regulation ability data were collected. fMRI data collected during a face viewing task was also available for 24 children.Results: Right amygdala-medial PFC (mPFC) functional connectivity was positively associated with child emotion regulation ability and negatively associated with child negative affect and right amygdala reactivity to facial expressions of emotion. Right amygdala-mPFC functional connectivity also statistically mediated the relationship between heightened right amygdala reactivity and elevated child negative affect.Conclusion: Study findings suggest that amygdala-mPFC functional connectivity during early childhood, and its relationships with amygdala reactivity and emotion regulation during this highly sensitive developmental period, may play an important role in early emotional development. These results inform the neurodevelopmental biology of emotion regulation and its potential relationship with risk for psychopathology.