Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly
Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly
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DOI：
10.1016/j.neurobiolaging.2012.10.022
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发表时间：
2013-04-01
影响因子：
4.2
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Rajagopalan, Priya;Refsum, Helga;Thompson, Paul M.
肾功能不佳与认知能力下降和全身性脑萎缩的风险增加有关。慢性肾脏疾病损害了肾小球滤过率，这种恶化表现为血液中肌酐和胱抑素C等肾脏生物标志物水平的升高。在此，我们假设肾功能受损可能与易发生神经变性的区域的脑缺陷有关。使用基于张量的形态计量学，我们在738名(平均年龄75.5+/-6.8岁；438名男性，300名女性)老年高加索受试者中，将脑体积差异的模式与肌酐、胱抑素C水平和肾小球滤过率联系起来，作为阿尔茨海默病神经成像计划的一部分。肾脏生物标志物的升高与大脑白质区域的体积缺陷有关。在我们的研究中，所有三个肾脏参数都显示出与内囊前肢两侧对应的区域一致的显著相关性。这是第一个报道与肾脏生物标记物升高相关的大脑结构变化的显著轮廓的研究，帮助我们解释认知缺陷。(C)2013 Elsevier Inc.保留所有权利。
Poor kidney function is associated with increased risk of cognitive decline and generalized brain atrophy. Chronic kidney disease impairs glomerular filtration rate, and this deterioration is indicated by elevated blood levels of kidney biomarkers such as creatinine and cystatin C. Here we hypothesized that impaired renal function would be associated with brain deficits in regions vulnerable to neurodegeneration. Using tensor-based morphometry, we related patterns of brain volumetric differences to creatinine, cystatin C levels, and glomerular filtration rate in a large cohort of 738 (mean age, 75.5 +/- 6.8 years; 438 men, 300 women) elderly Caucasian subjects scanned as part of the Alzheimer's Disease Neuroimaging Initiative. Elevated kidney biomarkers were associated with volume deficits in the white matter region of the brain. All 3 renal parameters in our study showed significant associations consistently with a region that corresponds with the anterior limb of internal capsule, bilaterally. This is the first study to report a marked profile of structural alterations in the brain associated with elevated kidney biomarkers, helping us to explain the cognitive deficits. (C) 2013 Elsevier Inc. All rights reserved.