HAND FOOT AND MOUTH DISEASE IN CHILDREN - AN EPIDEMIC ASSOCIATED WITH COXSACKIE VIRUS A-16
HAND FOOT AND MOUTH DISEASE IN CHILDREN - AN EPIDEMIC ASSOCIATED WITH COXSACKIE VIRUS A-16
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DOI：
10.1016/s0022-3476(65)80297-9
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发表时间：
1965-01-01
影响因子：
5.1
通讯作者：
LEIBOVITZ, A
中科院分区：
文献类型：
--
作者：
RICHARDSON, HB;LEIBOVITZ, A
1963年夏天，在亚利桑那州图森市的一个儿科门诊人群中，发生了一种流行的口炎，与手和脚上的水疱和主要发生在臀部的黄斑丘疹有关。利用组织培养技术进行病毒研究，从4名患者的囊泡、2名儿童的口腔刮痧和1名直肠拭子中检出柯萨奇病毒A-16。这些研究使用的是培养基L-15。本系列病例的临床和病毒数据与1957年多伦多、1959年英国加利福尼亚和伯明翰的流行病例进行了比较。最近报告的两例与柯萨奇A-16感染有关的婴儿死亡被引用为证据，证明照顾儿童的医生认识到这种疾病的重要性。
An epidemic of stomatitis associated with a vesicular exanthem on the hands and feet and a maculopapular eruption primarily on the buttocks occurring during the summer of 1963 in a pediatric outpatient population in Tucson, Arizona, is described. Virus studies, using tissue culture techniques, yielded Coxsackie virus A-16 from the vesicles of 4 patients, from the mouth scraping from 2 children, and from one rectal swab. Medium L-15 was used for these studies. The clinical and viral data of the patients in this series are compared with those of the epidemics in Toronto in 1957, and California and Birmingham, England, in 1959. Two infant deaths associated with Coxsackie A-16 infection recently reported are cited as evidence of the importance of recognizing this illness by physicians caring for children.