Enantioselective Steglich Rearrangement of Oxindole Derivatives by Easily Accessible Chiral N,N-4-(Dimethylamino)pyridine Derivatives
Enantioselective Steglich Rearrangement of Oxindole Derivatives by Easily Accessible Chiral N,N-4-(Dimethylamino)pyridine Derivatives
复制标题
DOI：
10.1021/acs.orglett.5b02089
复制
发表时间：
2015-09-18
期刊：
影响因子：
5.2
通讯作者：
Suga, Seiji
中科院分区：
文献类型：
--
作者：
Mandai, Hiroki;Fujiwara, Takuma;Suga, Seiji
手性N，N-4-（二甲氨基）吡啶（DMAP）衍生物可以通过Ugi多组分反应在一锅中制备，并有效地应用于氧吲哚衍生物的对映选择性Steglich重排，以高收率（约98%）和高对映选择性（高达99:1 er）得到含季碳中心的产物。
Chiral N,N-4-(dimethylamino)pyridine (DMAP) derivatives, which can be readily prepared by the Ugi multicomponent reaction in a one-pot manner, have been efficiently applied to the enantioselective Steglich rearrangement of oxindole derivatives to give the desired products bearing a quaternary carbon center in high yield (>98% yield) and with high enantioselectivity (up to 99:1 er).