Case-control resting-state fMRI study of brain functioning among adolescents with first-episode major depressive disorder.
Case-control resting-state fMRI study of brain functioning among adolescents with first-episode major depressive disorder.
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DOI：
10.3969/j.issn.1002-0829.2014.04.004
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
DU Y
中科院分区：
文献类型：
--
作者：
Gong Y;Hao L;Zhang X;Zhou Y;Li J;Zhao Z;Jiang W;DU Y
青少年抑郁症会给受影响的个人及其家庭成员带来严重和长期的痛苦，但这种致残性疾病的潜在机制仍不清楚。比较首发、未用药的青少年重度抑郁症患者与对照组的静息态脑功能。15名患有重度抑郁症的青少年和16名对照者接受了使用3 T磁共振扫描仪进行的静息状态fMRI扫描。低频波动幅度（ALFF）用于评估静息态脑功能。 抑郁青少年在儿童抑郁量表（CDI）上的平均（SD）得分高于对照组（22.13 [9.21] vs. 9.37 [5.65]）。与对照组相比，抑郁症青少年在扣带回后部、左侧颞下回、右侧上级颞回、右侧颞叶、右侧顶叶和右侧梭状回的ALFF较高;在双侧楔叶、左侧枕叶和左侧内侧额叶的ALFF较低。青少年抑郁症与大脑几个区域功能的显著变化有关。
Adolescent depression results in severe and protracted suffering for affected individuals and their family members, but the underlying mechanism of this disabling condition remains unclear. Compare resting-state brain functioning between first-episode, drug-naïve adolescents with major depressive disorder and matched controls. Fifteen adolescents with major depressive disorder and 16 controls underwent a resting-state fMRI scan performed using a 3T magnetic resonance scanner. The amplitude of low frequency fluctuation (ALFF) was used to assess resting-state brain function. Adolescents with depression had higher mean (sd) scores on the Children Depression Inventory (CDI) than controls (22.13 [9.21] vs. 9.37 [5.65]). Compared with controls, adolescents with depression had higher ALFF in the posterior cingulate gyrus, left inferior temporal gyrus, right superior temporal gyrus, right insula, right parietal lobe, and right fusiform gyrus; they also exhibited lower ALFF in the bilateral cuneus, the left occipital lobe, and the left medial frontal lobe. Adolescent depression is associated with significant changes in the functioning of several regions of the brain.