Stimulant medication treatment of target behaviors in children with autism: A population-based study
Stimulant medication treatment of target behaviors in children with autism: A population-based study
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DOI：
10.1097/dbp.0b013e31815f24f7
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发表时间：
2008-04-01
影响因子：
2.4
通讯作者：
Barbaresi, William J.
中科院分区：
文献类型：
--
作者：
Nickels, Katherine C.;Katusic, Slavica K.;Barbaresi, William J.
目的：本研究提供了有关刺激性药物治疗自闭症儿童多动、冲动、去抑制和注意力不集中等目标症状的详细信息。研究方法：在先前的研究中，1976-1997年在明尼苏达州奥姆斯特德县的所有0-21岁居民中确定了124名符合基于DSM-IV的自闭症研究标准的受试者。对于这124名研究确定患有自闭症的儿童中的每一个，提取所有处方精神药理学药物的信息。结果：124例受试者中，52.4%（N = 65）使用精神兴奋剂。精神兴奋剂治疗的中位总持续时间为4.0年。有398次精神兴奋剂治疗。有利的反应与69.4%的治疗事件相关。在398次兴奋剂治疗中，16.8%与记录的副作用有关。66%的儿童至少经历了一种副作用。结论：这些结果表明，精神兴奋剂通常用于自闭症儿童，并表明这些药物可能会改善多动，冲动，去抑制和注意力不集中的目标症状。
Objective: This study provides detailed information about stimulant medication treatment for the target symptoms of hyperactivity, impulsivity, disinhibition, and inattention in children with autism. Methods: In a previous study, 124 subjects fulfilling DSM-IV-based research criteria for autistic disorder were identified among all 0-21 year old residents of Olmsted County, MN from 1976-1997. For each of these 124 children with research-identified autism, information was abstracted on all prescribed psychopharmacological medications. Results: Psychostimulants were used to treat 52.4% (N = 65) of the 124 subjects. The median total duration of psychostimulant treatment was 4.0 years. There were 398 episodes of psychostimulant treatment. Favorable responses were associated with 69.4% of treatment episodes. Of the 398 episodes of stimulant treatment, 16.8% were associated with a documented side effect. At least one side effect was experienced by 66% of the children. Conclusion: These results indicate that psychostimulants are commonly prescribed for children with autism, and suggest that these medications may improve the target symptoms of hyperactivity, impulsivity, disinhibition and inattention.