Effects of prolonged exposure to anabolic steroids on the behavior of male and female mice
Effects of prolonged exposure to anabolic steroids on the behavior of male and female mice
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DOI：
10.1016/0091-3057(95)02030-6
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发表时间：
1996-02-01
影响因子：
3.6
通讯作者：
Bronson, FH
中科院分区：
文献类型：
--
作者：
Bronson, FH
成年雄性和雌性小鼠暴露于药理剂量的四种合成代谢-雄激素类固醇的组合6个月。根据生物测定，雄性暴露于5倍或20倍的雄性激素维持水平;雌性暴露于雄性维持水平的1倍或5倍。即使是低剂量也足以降低两种性别动物的性腺重量，并消除雌性动物的发情周期。类固醇治疗阻止了大多数男性的射精，但不影响其性行为的其他方面。在一些女性类固醇治疗引起男性样安装和骨盆推力。接触类固醇增加了女性的攻击性。使用不同的测试方案，类固醇暴露对男性的攻击性没有影响。类固醇治疗显著降低了女性的跑步轮使用率，男性略低。总的来说，本实验的结果表明，在男性中正常雄激素介导的行为没有增强，但对女性的行为有有效的影响。
Adult male and female mice were exposed to a combination of four anabolic-androgenic steroids at pharmacological doses for 6 months. Males were exposed to either 5 or 20 times androgenic maintenance levels, as determined by bioassay; females were exposed to either one or five times the maintenance levels for males. Even the low doses were sufficient to reduce gonadal weight in both sexes and eliminate the estrous cycle in females. Steroid treatment blocked ejaculation in most males without influencing other facets of their sexual behavior. In some females steroid treatment elicited male-like mounting and pelvic thrusting. Exposure to steroids increased aggressiveness in females. Using a different testing protocol, steroid exposure had no effect on aggressiveness in males. Steroid treatment decreased the use of a running wheel significantly in females and marginally in males. Overall, the results of this experiment suggest no enhancement of normal androgen-mediated behavior in males, but potent effects on the behavior of females.