Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives
Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives
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DOI：
10.1016/j.neuropsychologia.2009.12.019
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发表时间：
2010-04-01
期刊：
影响因子：
2.6
通讯作者：
Guinjoan, Salvador M.
中科院分区：
文献类型：
--
作者：
de Achaval, Delfina;Costanzo, Elsa Y.;Guinjoan, Salvador M.
先前的研究表明，精神分裂症患者的社会认知会受到影响。本研究的目的是探讨在何种程度上的社会认知缺陷是由未受影响的一级亲属共享，以及在不同的社会认知范式之间的关系的性质。招募了20名精神分裂症患者（7名女性，31 ± 10岁），20名年龄和性别匹配的健康个体，20名精神分裂症患者未受影响的一级亲属（11名女性，50 ± 20岁），以及20名年龄和性别匹配的健康个体。患者在检测社交假言（0.80 +/- 0.17 vs.对照组：0.94 +/- 0.09，p=0.025）和正确识别心理理论故事（0.71 +/- 0.13 vs.对照组：0.82 +/- 0.12，p=0.038）方面表现出缺陷。亲属在面孔测试中表现不佳（0.83 +/- 0.14 vs.对照组：0.9 +/- 0.08，p=0.048），阅读眼中的思想测试（0.59 +/- 0.17 vs.对照组：0.71 +/- 0.14，p = 0.046）和社交性假Pas的检测（0.8 +/- 0.2 vs.对照组：0.93 +/- 0.09，p=0.024）。患者及其亲属的年龄、受教育年限和一般认知表现与ababbraction无关。在情绪处理任务（面孔测试）的表现与心理理论测试的表现在健康的个人和精神分裂症患者的亲属只有。这些结果表明，精神分裂症患者和他们未受影响的一级亲属显示出相似但不相同的社会认知处理模式。(C)2009爱思唯尔有限公司保留所有权利。
Previous studies have suggested that social cognition is affected in individuals with schizophrenia. The purpose of this study was to explore to what extent social cognition deficits are shared by unaffected first-degree relatives, and the nature of the relationship between performance in different paradigms of social cognition. 20 Schizophrenia patients (7 females, 31 +/- 10 years), 20 healthy age- and gender-matched individuals, 20 unaffected first-degree relatives of the schizophrenia patients (11 females, 50 +/- 20 years), and 20 healthy individuals matched for age and gender were recruited. Patients showed deficits in the detection of social Faux Pas (0.80 +/- 0.17 vs. controls: 0.94 +/- 0.09, p=0.025) and the correct identification of Theory of Mind stories (0.71 +/- 0.13 vs. controls: 0.82 +/- 0.12, p=0.038). Relatives performed poorly in the Faces Test (0.83 +/- 0.14 vs. controls: 0.9 +/- 0.08, p=0.048), the Reading the Mind in the Eyes Test (0.59 +/- 0.17 vs. controls: 0.71 +/- 0.14, p = 0.046) and the detection of social Faux Pas (0.8 +/- 0.2 vs. controls: 0.93 +/- 0.09, p=0.024). Abnormalities were independent of age, years of education, and general cognitive performance in patients and their relatives. Performance in an Emotion Processing task (Faces Test) was correlated with performance in theory of mind tests in healthy individuals and relatives of patients with schizophrenia only. These results suggest that schizophrenia patients and their unaffected first-degree relatives display similar but nonidentical patterns of social cognition processing. (C) 2009 Elsevier Ltd. All rights reserved.