Age, Gender, and Race Effects on Cystatin C Levels in US Adolescents
Age, Gender, and Race Effects on Cystatin C Levels in US Adolescents
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DOI：
10.2215/cjn.00840208
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发表时间：
2008-11-01
影响因子：
9.8
通讯作者：
Furth, Susan
中科院分区：
文献类型：
--
作者：
Groesbeck, Darcy;Koettgen, Anna;Furth, Susan
背景和目标：本研究的目的是描述血清胱抑素C的正常范围，并确定与血清胱抑素C变异性相关的因素，与已知影响美国青少年人群肌酐水平的因素形成对比。在第三次全国健康与营养检查调查中，对719名12至19岁的参与者进行了血清胱抑素C和肌酐测定，1988年至1994年进行的全国性横断面调查。我们计算了性别和种族/种族特异性胱抑素C和肌酐的范围，并进行多变量线性回归分析，以评估因素，有助于胱抑素C和肌酐level.Results的变化：总体而言，平均血清胱抑素C水平为0.84毫克/升，男性高于女性的个人和非西班牙裔白色高于非西班牙裔黑人和墨西哥裔美国人的个人。平均血清肌酐为0.71 mg/dl，男性高于女性，但非西班牙裔白色和墨西哥裔美国人低于非西班牙裔黑人。与肌酐不同，肌酐随年龄从12岁增加到19岁，胱抑素C水平下降，特别是在女性个体中。调整后的年龄，性别，种族/民族，尿酸和血尿素氮显着相关与胱抑素C levels.Conclusions：血清胱抑素C是显着相关的性别，年龄，种族/民族，尿酸，血尿素氮在青少年。
Background and objectives: The objective of this study was to describe the normal range of serum cystatin C and identify factors associated with variability in serum cystatin C contrasting with factors that are known to influence creatinine levels in the general US adolescent population.Design, setting, participants, & measurements: Serum cystatin C and creatinine were measured in 719 participants aged 12 to 19 yr in the Third National Health and Nutrition Examination Survey, a national cross-sectional survey conducted in 1988 through 1994. We calculated gender- and race/ethnicity-specific cystatin C and creatinine ranges and conducted multivariable linear regression analyses to assess factors that contribute to variability in cystatin C and creatinine levels.Results: Overall, the mean serum cystatin C level was 0.84 mg/L and was higher in male than female individuals and higher in non-Hispanic white versus non-Hispanic black and Mexican American individuals. The mean serum creatinine was 0.71 mg/dl and was higher in male than in female individuals but lower in non-Hispanic white and Mexican American compared with non-Hispanic black individuals. Unlike creatinine, which increases with age from 12 to 19 yr, cystatin C levels decrease, particularly in female individuals. After adjustment for age, gender, and race/ethnicity, uric acid and blood urea nitrogen were significantly associated with cystatin C levels.Conclusions: Serum cystatin C is significantly related to gender, age, race/ethnicity, uric acid, and blood urea nitrogen in adolescents.