Forebrain c-fos expression under conditions conducive to pair bonding in female prairie voles (Microtus ochrogaster)
Forebrain c-fos expression under conditions conducive to pair bonding in female prairie voles (Microtus ochrogaster)
复制标题
DOI：
10.1016/s0031-9384(03)00226-9
复制
发表时间：
2003-10-01
影响因子：
2.9
通讯作者：
Wang, ZX
中科院分区：
文献类型：
--
作者：
Curtis, JT;Wang, ZX
在6小时内重复交配有助于一夫一妻制草原田鼠的配对形成。利用这种模式，我们研究了与田鼠社会行为有关的脑区fos的表达。我们假设，在一段足够的时间后，fos蛋白的存在足以发生成对键，这可能表明大脑区域在成对键形成中特别重要。我们发现，在6小时内多次交配的雌性中，杏仁核内侧和皮质、内侧视前区（MPOA）和终纹床核（BNST）的fos免疫反应性水平升高，与各种未交配的对照相比。在中央杏仁核、伏隔核（NAcc）或外侧隔（LS）中未发现治疗效果。我们认为，在伴侣结合发生足够时间后，有证据表明fos表达的区域可能在伴侣和交配刺激之间形成关联的过程中很重要。(C) 2003 Elsevier Inc.版权所有。
Repeated mating over a period of 6 h facilitates pair-bond formation in monogamous prairie voles. Using this paradigm, we examined fos expression in brain areas implicated in social behavior in voles. We hypothesized that the presence of the fos protein after a period of time sufficient for pair bonding to occur may indicate brain areas that are especially important in pair bond formation. We found elevated levels of fos immunoreactivity in the medial and cortical amygdala, medial preoptic area (MPOA), and bed nucleus of the stria terminalis (BNST) in females that mated several times over a 6-h period as compared to a variety of unmated controls. No treatment effects were found in the central amygdala, nucleus accumbens (NAcc), or lateral septum (LS). We suggest that areas that show evidence of fos expression after sufficient time for pair bonding to occur may be important in the formation of associations between the partner and mating stimuli. (C) 2003 Elsevier Inc. All rights reserved.