Specific in vivo binding of 77Br-p-bromospiroperidol in rat brain: a potential tool for gamma ray imaging.
Specific in vivo binding of 77Br-p-bromospiroperidol in rat brain: a potential tool for gamma ray imaging.
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77Br-p-bromospiroperidol 在大鼠脑中的特异性体内结合：伽马射线成像的潜在工具。
DOI：
10.1016/0024-3205(81)90298-8
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Friedman,AM
中科院分区：
文献类型：
--
作者：
Kulmala,HK;Huang,CC;Dinerstein,RJ;Friedman,AM
在体内检查了 γ 标记的精神安定药 77 Br-p-bromosprioperidol 在大鼠脑中的结合。这种结合与 3 H-螺哌啶醇的结合平行，因为该结合在多巴胺能神经支配的区域特别高，是可饱和的，并且被高剂量的未标记螺哌啶醇取代 (1-5)。因此， 77 Br-p-溴螺哌啶醇是用于体内受体结合监测的伽马射线成像技术的合适配体。
The binding of the gamma labeled neuroleptic, 77 Br-p-bromosprioperidol, in the rat brain was examined in vivo. This binding parallels the binding of 3 H-spiroperidol, in that binding is especially high in dopaminergically innervated areas, is saturable, and is displaced by high doses of unlabeled spiroperidol (1–5). Thus, 77 Br-p-bromospiroperidol is a suitable ligand for use in gamma ray imaging techniques for in vivo monitoring of receptor binding.