Mechanical stimulation in the form of vibration prevents postmenopausal bone loss in ovariectomized rats
Mechanical stimulation in the form of vibration prevents postmenopausal bone loss in ovariectomized rats
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DOI：
10.1007/s002239900566
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发表时间：
1998-12-01
影响因子：
4.2
通讯作者：
Lyritis, G
中科院分区：
文献类型：
--
作者：
Flieger, J;Karachalios, T;Lyritis, G
骨质疏松症的治疗方法有哪些？然而，它在成年期的确切作用和有效性尚不清楚。虽然长时间的剧烈运动可以提高骨密度，但很少有成年人遵守这样的训练计划。本研究评价了非生理性机械刺激的影响，在低强度振动的形式（频率：50 Hz，加速度：2克，30分钟/天，5天/周），对预防绝经后骨质疏松症的动物模型中的骨丢失。在卵巢切除组的大鼠中，在卵巢切除术后5周记录到骨密度（股骨和胫骨）的统计学显著（p < 0.05）降低。这种效果在12周的研究期间得以维持。振动预防卵巢切除术后早期骨丢失。在第5周，与卵巢切除对照组相比，振动卵巢切除大鼠的BMD值在统计学上显著更高（p < 0.05）。振动不影响SHAM手术大鼠的骨密度。尽管振动增加了卵巢切除大鼠的极限强度（大鼠股骨的断裂载荷），但这一发现在统计学上并不显着。我们的数据表明，这种振动平台形式的安全且易于应用的振动方法在动物模型中可有效预防卵巢切除术后早期骨丢失。
Physical exercise is recommended for the prevention and treatment of osteoporosis. However, its exact role and effectiveness in adulthood is unclear. While vigorous exercise of long duration enhances bone density, few adult individuals comply with such training programs. The present study evaluates the influence of nonphysiological mechanical stimulation, in the form of low intensity vibration (frequency: 50 Hz, acceleration: 2 g, 30 min/day for 5 days/week), on the prevention of bone loss in an animal model of postmenopausal osteoporosis. In the ovariectomised groups of rats a statistically significant (p < 0.05) decrease of bone density (femur and tibia) was recorded at 5 weeks postovariectomy. This effect was maintained for the 12 week duration of the study. Vibration prevented early bone loss after ovariectomy. Vibrated ovariectomised rats showed statistically significantly higher (p < 0.05) BMD values compared to those of their ovariectomised controls at 5 weeks. Vibration did not influence the bone density of the SHAM-operated rats. Although vibration increased ultimate strength (fracture load of the rat femur) in the ovariectomised rats, this finding was not statistically significant. Our data indicate that this method of safe and easily applicable vibration, in the form of a vibrating platform, is effective in preventing early postovariectomy bone loss in an animal model.