THE EFFECTS OF DIETARY SUPPLEMENTATION WITH FISH OIL LIPIDS ON THE AIRWAYS RESPONSE TO INHALED ALLERGEN IN BRONCHIAL-ASTHMA
THE EFFECTS OF DIETARY SUPPLEMENTATION WITH FISH OIL LIPIDS ON THE AIRWAYS RESPONSE TO INHALED ALLERGEN IN BRONCHIAL-ASTHMA
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DOI：
10.1164/ajrccm/139.6.1395
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发表时间：
1989-06-01
期刊：
影响因子：
--
通讯作者：
LEE, TH
中科院分区：
文献类型：
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作者：
ARM, JP;HORTON, CE;LEE, TH
在17名特应性哮喘受试者中研究了膳食补充鱼油脂质对气道对过敏原和中性粒细胞生物化学和功能的反应的影响。9名受试者每天接受18粒Max-EPA胶囊（3.2 g二十碳五烯酸和2.2 g二十二碳六烯酸），8名受试者接受含有橄榄油的相同胶囊，以双盲方式持续10周。饮食前值和饮食补充Max-EPA或安慰剂后观察到的过敏原剂量之间没有差异，过敏原剂量引起急性哮喘反应，通过比气道传导性（PD 35）下降35%，皮肤点刺试验过敏原的消退剂量，组胺PD 35或总血清IgE浓度进行评估。17名受试者中有12名在过敏原激发后出现迟发性哮喘反应。其中6名受试者接受Max-EPA，6名接受安慰剂胶囊。与饮食前值相比，在饮食补充Max-EPA（p < 0.005）而不是安慰剂后，过敏原诱导的晚期哮喘反应的幅度在过敏原激发后2至7小时显著减弱。晚期反应的减弱并不伴随着疾病临床严重程度的任何显著变化，如通过昼夜呼气峰流速、症状评分或支气管扩张剂药物使用评估的。与饮食前值相比，中性粒细胞EPA含量增加了10倍，中性粒细胞对甲酰-甲硫氨酰-亮氨酰-苯丙氨酸的趋化反应被抑制了约50%，在饮食补充Max-EPA后，由钙离子载体刺激的中性粒细胞产生的白三烯B4平均抑制了47%，但在安慰剂后没有。
The effects of dietary supplementation with fish oil lipids on the airways responses to allergen and neutrophil biochemistry and function have been studied in 17 atopic asthmatic subjects. Nine subjects received 18 capsules of Max-EPA (3.2 g eicosapentaenoic acid and 2.2 g docosahexaenoic acid) a day and eight subjects received identical capsules containing olive oil, for 10 wk in a double-blind fashion. There were on differences between prediet values and those observed after dietary supplementation with Max-EPA or placebo in the dose of allergen causing an acute asthmatic response as assessed by a 35% fall in specific airways conductance (PD35), the extinction dose of allergen on skin prick testing, the histamine PD35, or the total serum IgE concentrations. Twelve of the 17 subjects developed late asthmatic responses after allergen challenge prediet. Six of these subjects received Max-EPA, and six received placebo capsules. As compared to prediet values, the magnitude of the allergen-induced late asthmatic response was significantly attenuated from 2 to 7 h after allergen challenge following dietary supplementation with Max-EPA (p < 0.005) but not with placebo. The attenuation of the late response was not accompanied by any significant change in the clinical severity of disease as assessed by diurnal peak expiratory flow rates, symptom scores, or bronchodilator drug usage. As compared to prediet values, there was a 10-fold increase in neutrophil EPA content, neutrophil chemotactic responses to formyl-methionyl-leucyl-phenylalanine were depressed by approximately 50%, and there was a mean 47% inhibition of leukotriene B4 generation by neutrophils stimulated by the calcium ionophore after dietary supplementation with Max-EPA but not after placebo.