Precision and diversity in an odor map on the olfactory bulb
Precision and diversity in an odor map on the olfactory bulb
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DOI：
10.1038/nn.2262
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发表时间：
2009-02-01
影响因子：
25
通讯作者：
Meister, Markus
中科院分区：
文献类型：
--
作者：
Soucy, Edward R.;Albeanu, Dinu F.;Meister, Markus
我们探索了大鼠和小鼠嗅球上肾小球形成的气味空间图。确定的肾小球可以通过动物对数百种气味的反应来匹配。它们在不同个体中的布局变化仅类似于1个肾小球间距，对应于1000分之一的精度。在不同的物种中，小鼠和大鼠共享许多具有明显相同气味调节的肾小球，它们以相似的布局排列。在将肾小球的位置映射到它的气味调节时，我们发现只有一个粗略的关系，精度类似于5个间隔。在更细的尺度上没有明显的化学变化顺序，近肾小球的气味敏感性几乎和远肾小球一样多样。这种感觉调节的局部多样性与其他脑图有明显区别。鉴于肾小球的可靠位置，它代表了嗅球的特征，而不是缺陷。
We explored the map of odor space created by glomeruli on the olfactory bulb of both rat and mouse. Identified glomeruli could be matched across animals by their response profile to hundreds of odors. Their layout in different individuals varied by only similar to 1 glomerular spacing, corresponding to a precision of 1 part in 1,000. Across species, mouse and rat share many glomeruli with apparently identical odor tuning, arranged in a similar layout. In mapping the position of a glomerulus to its odor tuning, we found only a coarse relationship with a precision of similar to 5 spacings. No chemotopic order was apparent on a finer scale and nearby glomeruli were almost as diverse in their odor sensitivity as distant ones. This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb.