Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het)-S and S=O Bond Cleavage
Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het)-S and S=O Bond Cleavage
复制标题
通过 C(Het)-S 和 S=O 键断裂，富电子 (Het) 芳烃与氟烷基杂芳基砜的无过渡金属亲电子氟烷亚磺酰化
DOI：
10.1002/adsc.201900959
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发表时间：
2019
影响因子：
5.4
通讯作者：
Hu Jinbo
中科院分区：
文献类型：
--
作者：
Wei Jun;Bao Kun;Qi Chengcheng;Liu Yao;Ni Chuanfa;Sheng Rong;Hu Jinbo
以氟代烷基杂芳基砜（Rf= C4 F9、CF2 Cl、CF2 Br和CF2 COOEt）为RfSO源，研究了一种新的Ph 2 P（O）Cl-介导的富电子芳烃的直接氟代烷基亚磺酰化反应.这是第一个2-HetSO 2 Rf在有机合成中通过C（Het）−S和S=O键断裂作为RfSO合成子的例子。
A novel Ph2P(O)Cl‐mediated direct fluoroalkanesulfinylation of electron‐rich (het)arenes using fluoroalkyl heteroaryl sulfones as the RfSO source (Rf=C4F9, CF2Cl, CF2Br, and CF2COOEt) was developed. This is the first example where 2‐HetSO2Rfperforms as the RfSO synthon in organic synthesis via both C(Het)−S and S=O bond cleavage.