Functional and immunologic protein S levels are decreased during pregnancy.
Functional and immunologic protein S levels are decreased during pregnancy.
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DOI：
10.1182/blood.v68.4.881.881
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发表时间：
1986
期刊：
影响因子：
20.3
通讯作者：
P. Comp;G. R. Thurnau;J. Welsh;C. T. Esmon
中科院分区：
文献类型：
--
作者：
P. Comp;G. R. Thurnau;J. Welsh;C. T. Esmon
蛋白S是一种天然抗凝蛋白，是活化蛋白c的辅助因子。在怀孕和产后，与未怀孕女性（97% +/- 31.6%）相比，功能蛋白S水平显著降低（38% +/- 17.3%，平均+/- 1 SD） （P < 0.001）。在血浆中，功能活跃的游离蛋白S和功能失活的c4b结合蛋白S之间存在平衡。由于这种平衡，总蛋白S抗原水平的降低或c4b结合蛋白水平的升高都可能导致蛋白S活性的降低。酶联免疫法测定的c4b结合蛋白水平在孕妇和非孕妇对照组中没有显著差异（103.5% +/- 21.2% v 100% +/- 16.9%）。然而，在怀孕和产后期间，总蛋白S水平比未怀孕的对照组（100% +/- 17.0%）降低（68% +/- 10.7%）。这种差异在P < 0.001时具有显著性。这些数据表明，在怀孕期间观察到的蛋白S活性降低是总蛋白S抗原减少的结果。
Protein S, is a natural anticoagulant protein which serves as a cofactor for activated protein C. During pregnancy and in the postpartum period, functional protein S levels are significantly reduced (38% +/- 17.3%, mean +/- 1 SD) when compared to nonpregnant females (97% +/- 31.6%) (P less than 0.001). In plasma an equilibrium exists between functionally active free protein S and protein S complexed with C4b-binding protein, which is functionally inactive. As a result of this equilibrium either a decreased level of total protein S antigen or an elevation of C4b-binding protein could lead to reduced protein S activity. C4b-binding protein levels measured by enzyme-linked immunoassay are not significantly different in pregnant women versus nonpregnant controls (103.5% +/- 21.2% v 100% +/- 16.9%). However, during pregnancy and in the postpartum period, total protein S levels are reduced (68% +/- 10.7%) compared to nonpregnant controls (100% +/- 17.0%). This difference is significant at P less than 0.001. These data demonstrated that the reduction in protein S activity observed during pregnancy is a result of reduced total protein S antigen.