In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study
In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study
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DOI：
10.1016/j.jinf.2017.08.010
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发表时间：
2017-11-01
影响因子：
28.2
通讯作者：
Danquah, Ina
中科院分区：
文献类型：
--
作者：
Bedu-Addo, George;Alicke, Marie;Danquah, Ina
目的：妊娠期疟疾(MIP)可导致胎儿营养不良和不良的出生结局，并可能构成子代代谢性疾病的发育源。在加纳的出生队列中，我们研究了青春期接触MIP与代谢特征的关系。方法：对155对母子在分娩时进行MIP评估。在现在十几岁的儿童(平均年龄14.8岁，其中53%是男性)中，我们测量了空腹血糖(FPG)、体重指数(BMI)以及收缩和舒张压(BP)。结果：在分娩时，45%的孕妇暴露于三聚氰胺，使青春期的空腹血糖升高，调整了母亲分娩时的年龄、胎次和家庭社会经济状况(感染与未感染：平均增量空腹血糖=0.20mmoL/L；95%可信区间：0.01，0.39；p=0.049)。作为一种趋势，这对BP来说是明显的，特别是对于微观感染(平均增量收缩压=5.43毫米汞柱；95%可信区间：0.00，10.88；p=0.050；平均舒张压=3.67毫米汞柱；95%可信区间：-0.81，8.14；p=0.107)。这些关联在很大程度上与出生体重、胎龄和青少年BMI无关。青少年BMI与MIP无关。结论：在加纳农村，胎儿发育期间暴露于疟疾可促进成年后的代谢状况。(C)2017年作者。由爱思唯尔有限公司代表英国感染协会出版。
Objectives: Malaria in pregnancy (MiP) contributes to fetal undernutrition and adverse birth outcomes, and may constitute a developmental origin of metabolic diseases in the offspring. In a Ghanaian birth cohort, we examined the relationships between MiP-exposure and metabolic traits in adolescence.Methods: MiP at delivery was assessed in 155 mother-child pairs. Among the now teenaged children (mean age, 14.8 years; 53% male), we measured fasting plasma glucose (FPG), body mass index (BMI), and systolic and diastolic blood pressure (BP). Associations of MiP with the adolescents' FPG, BMI, and BP were examined by linear regression.Results: At delivery, 45% were MiP-exposed, which increased FPG in adolescence, adjusted for mother's age at delivery, parity and familial socio-economic status (infected vs. uninfected: mean Delta FPG = 0.20 mmol/L; 95% confidence interval (CI): 0.01, 0.39; p = 0.049). As a trend, this was discernible for BP, particularly for microscopic infections (mean Delta systolic BP = 5.43 mmHg; 95% CI: 0.00, 10.88; p = 0.050; mean.diastolic BP = 3.67 mmHg; 95% CI: -0.81, 8.14; p = 0.107). These associations were largely independent of birth weight, gestational age and teenage BMI. Adolescent BMI was not related to MiP.Conclusions: In rural Ghana, exposure to malaria during fetal development contributes to metabolic conditions in young adulthood. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association.