Seroprevalence of Toxoplasma gondii IgG antibody in HIV/AIDS-infected individuals in Maputo, Mozambique
Seroprevalence of Toxoplasma gondii IgG antibody in HIV/AIDS-infected individuals in Maputo, Mozambique
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DOI：
10.1590/s0034-8910.2013047004661
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发表时间：
2013-10-01
影响因子：
2.8
通讯作者：
Ramos, Alberto Novaes, Jr.
中科院分区：
文献类型：
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作者：
Domingos, Abilio;Ito, Lucy Sayuri;Ramos, Alberto Novaes, Jr.
目的：分析2010年莫桑比克马普托某实验室收治的200例HIV/AIDS患者的社会人口学资料和实验室检查结果，分析弓形虫抗体在HIV/AIDS患者中的流行情况及其与人口统计学和社会变量的关系。所有参与者的个人数据都是通过自填式问卷收集的。对血浆标本进行抗T。用血凝试验检测弓形虫抗体。结果：血清中抗弓形虫抗体的抗体阳性率为100%。男性为46.0%(95%CI为39.2；52.9)，女性为50.9%(95%CI为41.9；59.8)，男性为39.3%(95%CI为29.5；50.0)，性别差异无统计学意义(OR为1.30；95%CI为0.95；1.77；p=0.12)。年龄从10岁到60岁不等，年龄越大，感染率越高，但两者之间没有显著差异。经常食用牛肉(OR1.74；95%CI1.04；2.89，P=0.05)、饲养猫狗(OR6.18；95%CI3.60；10.62，p<；0.000)和经常接触土壤(OR3.38；95%CI2.19；5.21；p<；0.000)与潜在感染风险显著相关。文化和行为方面会增加风险。在我们的环境中，与艾滋病毒/艾滋病患者的脑膜脑损伤相关的发病率和死亡率的巨大负担可能是弓形虫病的责任。
OBJECTIVE: To analyze the prevalence of IgG antibodies to Toxoplasma gondii in patients infected with HIV/AIDS and the association of demographic and social variables.METHODS: Descriptive cross-sectional study that included the analysis of sociodemographic data and laboratory findings of 200 patients infected with HIV/AIDS treated in a laboratory unit in Maputo, Mozambique, in 2010. Individual data for all participants were collected with a self-administered questionnaire. Plasma samples were tested for IgG testing of anti-T. gondii using hemagglutination for the analysis of antibodies.RESULTS: The seroprevalence of IgG anti-T. gondii was 46.0% (95% CI 39.2; 52.9), 39.3% (95% CI 29.5; 50.0) in men and 50.9% (95% CI 41.9; 59.8) in women, with no difference between sex (OR 1.30; 95% CI 0.95; 1.77; p = 0.12). Ages ranged from 10 to 60 years, with a higher prevalence of infection in older age groups, but with no significant difference between them. Regularly consuming cattle meat (OR 1.74; 95% CI 1.04; 2.89, p = 0.05), breeding cats/dogs (OR 6.18; 95% CI 3.60; 10.62, p < 0.000) and having regular contact with soil (OR 3.38; 95% CI 2.19; 5.21; p < 0.000) were significantly associated with risk of latent infection.CONCLUSIONS: Toxoplasmosis is an infection with high prevalence in Mozambique. Cultural and behavioral aspects increase the risk. Toxoplasmosis can be responsible in our environment by the great burden of morbidity and mortality associated with meningoencephalic injuries in patients with HIV/AIDS.