MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer.
MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer.
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DOI：
10.3389/fcell.2022.828128
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发表时间：
2022
影响因子：
5.5
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中科院分区：
文献类型：
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结直肠癌(CRC)是最常见的癌症类型之一，也是世界范围内主要的死亡原因之一。MicroRNAs(MiRNAs)在正常的细胞维持、发育和其他生理过程中发挥着核心作用。越来越多的证据表明，调节异常的miRNAs可以参与肿瘤的发生、发展、转移和治疗耐药，从而使miRNAs成为结直肠癌的临床生物标志物和治疗靶点。MiRNAs通过与靶基因的3‘-非翻译区(3’-UTR)结合，在转录后水平上导致靶基因mRNA的降解或抑制。在过去的十年中，研究发现了大量的miRNAs及其潜在的靶点，但在结直肠癌中miRNA/靶点的复杂网络仍不清楚。在这篇综述中，我们试图用最新的、高质量的公开数据总结miRNA靶向调控网络(Wnt、转化生长因子-β、PI3K-AKT、MAPK和EMT相关通路)在结直肠癌中的复杂作用。特别是，我们的目标是讨论特定途径的下游miRNAs。我们希望这些数据能成为规范的miRNA靶向调控网络的有力补充。
Colorectal cancer (CRC) is one of the most common types of cancer and one of the leading causes of mortality worldwide. MicroRNAs (miRNAs) play central roles in normal cell maintenance, development, and other physiological processes. Growing evidence has illustrated that dysregulated miRNAs can participate in the initiation, progression, metastasis, and therapeutic resistance that confer miRNAs to serve as clinical biomarkers and therapeutic targets for CRC. Through binding to the 3′-untranslated region (3′-UTR) of target genes, miRNAs can lead to target mRNA degradation or inhibition at a post-transcriptional level. During the last decade, studies have found numerous miRNAs and their potential targets, but the complex network of miRNA/Targets in CRC remains unclear. In this review, we sought to summarize the complicated roles of the miRNA-target regulation network (Wnt, TGF-β, PI3K-AKT, MAPK, and EMT related pathways) in CRC with up-to-date, high-quality published data. In particular, we aimed to discuss the downstream miRNAs of specific pathways. We hope these data can be a potent supplement for the canonical miRNA-target regulation network.