A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory
A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory
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DOI：
10.1016/j.nbt.2012.03.004
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发表时间：
2012-09-15
影响因子：
5.4
通讯作者：
Flores, Mauricio
中科院分区：
文献类型：
--
作者：
Hood, Leroy;Flores, Mauricio
系统生物学和数字革命将医疗保健转变为一种积极的P4药物，具有预测性，预防性，个性化和参与性。系统生物学 - 整体，全球和综合方法 - 引起了系统医学，这是一种健康和疾病的系统方法。系统医学有望（1）对疾病机制提供深入的见解，（2）使血液成为观察个人健康和疾病的诊断窗口，（3）将复杂性疾病分类为其独特的亚型，以使其针对适当的药物进行阻抗匹配，（（ 4）提供新的药物靶标发现方法，（5）产生用于评估健康的指标。 P4 Medicine是系统医学的临床面孔，具有两个主要目标：量化健康和脱神经疾病。患者和消费者将通过参与旨在改善自己的医疗保健的医学指导社交网络来实现P4医学的主要驱动力。 P4 Medicine对社会具有惊人的影响 - 包括能够扭转不断提高医疗保健成本的能力。将P4药物带给患者和消费者的挑战是双重的：首先，发明将启用P4医学的策略和技术，其次是处理P4医学对社会的影响，包括关键的道德，社会，法律，法规和经济，问题。管理社会问题将面临最重大的挑战。为了将P4药物带给患者，需要各种类型的战略合作伙伴关系。
Systems biology and the digital revolution are together transforming healthcare to a proactive P4 medicine that is predictive, preventive, personalized and participatory. Systems biology - holistic, global and integrative in approach - has given rise to systems medicine, a systems approach to health and disease. Systems medicine promises to (1) provide deep insights into disease mechanisms, (2) make blood a diagnostic window for viewing health and disease for the individual, (3) stratify complex diseases into their distinct subtypes for a impedance match against proper drugs, (4) provide new approaches to drug target discovery and (5) generate metrics for assessing wellness. P4 medicine, the clinical face of systems medicine, has two major objectives: to quantify wellness and to demystify disease. Patients and consumers will be a major driver in the realization of P4 medicine through their participation in medically oriented social networks directed at improving their own healthcare. P4 medicine has striking implications for society - including the ability to turn around the ever-escalating costs of healthcare. The challenge in bringing P4 medicine to patients and consumers is twofold: first, inventing the strategies and technologies that will enable P4 medicine and second, dealing with the impact of P4 medicine on society - including key ethical, social, legal, regulatory, and economic issues. Managing the societal problems will pose the most significant challenges. Strategic partnerships of a variety of types will be necessary to bring P4 medicine to patients.