Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits.
Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits.
复制标题
DOI：
10.3174/ajnr.a5339
复制
发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Mathuranath PS
中科院分区：
文献类型：
--
作者：
Sheelakumari R;Kesavadas C;Varghese T;Sreedharan RM;Thomas B;Verghese J;Mathuranath PS
脑铁沉积已被认为是神经退行性变的病理生理学的主要罪魁祸首。然而，尚未对行为变异性额颞叶痴呆（bvFTD）和原发性进行性失语症（PPA）患者的大脑进行铁的定量评估。我们研究的目的是使用磁敏感加权成像研究FTD亚型的特征性铁水平，并报告其与行为特征的相关性。这项前瞻性研究包括46例FTD患者（34例bvFTD和12例PPA）和34例年龄匹配的正常对照。我们对所有受试者进行了行为和神经心理评估。采用SWI定量测定上级额回、颞极、中央前回、基底节、扣带回前部、额叶白色质、海马头体、红核、黑质、齿状核和齿状核的铁负荷。进行线性回归分析，以将患者的铁含量与行为评分相关联。bvFTD组双侧上级额颞回、扣带回前部、壳核、右侧中央前回、海马、红核铁含量均高于对照组。PPA患者左侧上级颞回铁水平升高。此外，右侧上级额上回铁沉积可区分bvFTD和PPA。情感淡漠与上级脑回铁含量、抑制解除与壳核铁含量显著相关。使用SWI定量评估铁沉积可作为FTD诊断工作中的新生物标志物，并有助于区分FTD亚型。
Brain iron-deposition has been implicated as a major culprit in the pathophysiology of neurodegeneration. However, the quantitative assessment of iron in behavioralvariant frontotemporal dementia (bvFTD and primary progressive aphasia (PPA) brains has not been performed. The aim of our study was to investigate the characteristic iron levels in the FTD subtypes using susceptibility weighted imaging, and report its association with behavioural profiles. This prospective study included 46 FTD patients (34 bvFTD and 12 PPA) and 34 age-matched normal controls. We performed behavioural and neuropsychological assessment in all the subjects. The quantitative iron load was determined on SWI in the superior frontal gyrus and temporal pole, precentral gyrus, basal ganglia, anterior cingulate, frontal white matter, head and body of hippocampus, red nucleus, substantia nigra, insula and dendate nucleus. A linear regression analysis was performed to correlate between iron content and behavioural scores in patients. The iron content of bilateral superior frontal and temporal gyrus, anterior cingulate, putamen, right hemispheric precentral gyrus, insula, hippocampus and red nucleus was higher in bvFTD than controls. PPA patients had increased iron levels in the left superior temporal gyrus. In addition, right superior frontal gyrus iron deposition discriminated bvFTD from PPA. A significant correlation was found between apathy and iron content in superior frontal gyrus, and disinhibition and iron content in putamen. Quantitative assessment of iron deposition using SWI may serve as a new biomarker in the diagnostic work up of FTD and help distinguish FTD subtypes.